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Title: Development and characterization of a nanocarrier for quercetin
Authors: Wong, M.-Y.
Chiu, G.N.C. 
Keywords: Cholesterol free liposomes
Issue Date: Feb-2009
Citation: Wong, M.-Y.,Chiu, G.N.C. (2009-02). Development and characterization of a nanocarrier for quercetin. International Journal of Nanoscience 8 (1-2) : 175-179. ScholarBank@NUS Repository.
Abstract: Quercetin is a naturally occurring cytotoxic compound where clinical use has been limited by its low water solubility. Therefore, liposomes were explored for solubilizing quercetin. Liposomes composed of DPPC (1,2 dipalmitoyl-sn-glycerol-3-phosphocholine)/DSPE-PEG2000 (1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)2000])/quercetin (90:5:5 mole ratio) incorporated quercetin efficiently at 100.9 ± 4.6% and increased quercetin concentration in water 11.2-fold. Stability studies at storage temperature of 4°C showed that the liposomes were stable for up to 16 weeks, without any significant changes in diameters. Liposomal quercetin showed a delayed release profile and reduced quercetin degradation. In vitro cytotoxicity tests also showed that the ED 50 of liposomal quercetin was 17.6 times lower than free quercetin in MDA-MB-231 breast cancer cells. In conclusion, the DPPC/DSPE-PEG-based liposomes were stable and were capable of solubilizing quercetin, preventing quercetin degradation, and increasing quercetin in vitro cytotoxicity. Hence, liposomes are a suitable nanocarrier for quercetin. © 2009 World Scientific Publishing Company.
Source Title: International Journal of Nanoscience
ISSN: 0219581X
Appears in Collections:Staff Publications

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