Please use this identifier to cite or link to this item: https://doi.org/10.1093/nar/gkr284
Title: Update of PROFEAT: A web server for computing structural and physicochemical features of proteins and peptides from amino acid sequence
Authors: Rao, H.B.
Zhu, F. 
Yang, G.B.
Li, Z.R.
Chen, Y.Z. 
Issue Date: 1-Jul-2011
Citation: Rao, H.B., Zhu, F., Yang, G.B., Li, Z.R., Chen, Y.Z. (2011-07-01). Update of PROFEAT: A web server for computing structural and physicochemical features of proteins and peptides from amino acid sequence. Nucleic Acids Research 39 (SUPPL. 2) : W385-W390. ScholarBank@NUS Repository. https://doi.org/10.1093/nar/gkr284
Abstract: Sequence-derived structural and physicochemical features have been extensively used for analyzing and predicting structural, functional, expression and interaction profiles of proteins and peptides. PROFEAT has been developed as a web server for computing commonly used features of proteins and peptides from amino acid sequence. To facilitate more extensive studies of protein and peptides, numerous improvements and updates have been made to PROFEAT. We added new functions for computing descriptors of protein-protein and protein-small molecule interactions, segment descriptors for local properties of protein sequences, topological descriptors for peptide sequences and small molecule structures. We also added new feature groups for proteins and peptides (pseudo-amino acid composition, amphiphilic pseudo-amino acid composition, total amino acid properties and atomic-level topological descriptors) as well as for small molecules (atomic-level topological descriptors). Overall, PROFEAT computes 11 feature groups of descriptors for proteins and peptides, and a feature group of more than 400 descriptors for small molecules plus the derived features for protein-protein and protein-small molecule interactions. Our computational algorithms have been extensively tested and used in a number of published works for predicting proteins of specific structural or functional classes, protein-protein interactions, peptides of specific functions and quantitative structure activity relationships of small molecules. PROFEAT is accessible free of charge at http://bidd.cz3.nus.edu.sg/cgi-bin/prof/protein/ profnew.cgi. © 2011 The Author(s).
Source Title: Nucleic Acids Research
URI: http://scholarbank.nus.edu.sg/handle/10635/106485
ISSN: 03051048
DOI: 10.1093/nar/gkr284
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

92
checked on Jan 22, 2020

WEB OF SCIENCETM
Citations

79
checked on Jan 22, 2020

Page view(s)

70
checked on Jan 25, 2020

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.