Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.biomaterials.2012.01.024
DC FieldValue
dc.titleTranslocation mechanisms of chemically functionalised carbon nanotubes across plasma membranes
dc.contributor.authorLacerda, L.
dc.contributor.authorRussier, J.
dc.contributor.authorPastorin, G.
dc.contributor.authorHerrero, M.A.
dc.contributor.authorVenturelli, E.
dc.contributor.authorDumortier, H.
dc.contributor.authorAl-Jamal, K.T.
dc.contributor.authorPrato, M.
dc.contributor.authorKostarelos, K.
dc.contributor.authorBianco, A.
dc.date.accessioned2014-10-29T02:00:25Z
dc.date.available2014-10-29T02:00:25Z
dc.date.issued2012-04
dc.identifier.citationLacerda, L., Russier, J., Pastorin, G., Herrero, M.A., Venturelli, E., Dumortier, H., Al-Jamal, K.T., Prato, M., Kostarelos, K., Bianco, A. (2012-04). Translocation mechanisms of chemically functionalised carbon nanotubes across plasma membranes. Biomaterials 33 (11) : 3334-3343. ScholarBank@NUS Repository. https://doi.org/10.1016/j.biomaterials.2012.01.024
dc.identifier.issn01429612
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/106465
dc.description.abstractUnderstanding the mechanisms responsible for carbon nanotube (CNT) internalisation into live cells is considered critical both from a fundamental point of view and for further engineering of CNT-based delivery systems to intracellular targets. While several studies are focused on the development of such CNT-based delivery systems, attempts to systematically elucidate the cellular uptake mechanisms of CNTs are still rather limited. The aim of the present study is to evaluate the cellular internalisation of chemically functionalised multi-walled carbon nanotubes (f-MWCNTs) in the presence of different well-known cellular uptake inhibitors. Our data reveal how f-MWCNTs are able to translocate across cell membranes of both phagocytic and non-phagocytic cell lines. We have evidenced that at least 30-50% of f-MWCNTs are taken up by cells through an energy-independent mechanism. This characteristic makes nanotubes loaded with therapeutic or diagnostic cargos extremely interesting as the release of active molecules directly into the cytoplasm increase their biological activity and therapeutic efficacy. © 2012 Elsevier Ltd.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.biomaterials.2012.01.024
dc.sourceScopus
dc.subjectCarbon nanotubes
dc.subjectCell uptake
dc.subjectEndocytosis
dc.subjectInhibitors
dc.subjectNanomaterials
dc.subjectPhagocytosis
dc.typeArticle
dc.contributor.departmentPHARMACY
dc.description.doi10.1016/j.biomaterials.2012.01.024
dc.description.sourcetitleBiomaterials
dc.description.volume33
dc.description.issue11
dc.description.page3334-3343
dc.description.codenBIMAD
dc.identifier.isiut000301561300024
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.