Please use this identifier to cite or link to this item:
https://doi.org/10.1046/j.1365-2710.1998.00190.x
DC Field | Value | |
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dc.title | Stability of captopril in invert sugar solution | |
dc.contributor.author | Sam, W.J. | |
dc.contributor.author | Ho, P.C. | |
dc.date.accessioned | 2014-10-29T01:58:47Z | |
dc.date.available | 2014-10-29T01:58:47Z | |
dc.date.issued | 1998 | |
dc.identifier.citation | Sam, W.J., Ho, P.C. (1998). Stability of captopril in invert sugar solution. Journal of Clinical Pharmacy and Therapeutics 23 (6) : 451-456. ScholarBank@NUS Repository. https://doi.org/10.1046/j.1365-2710.1998.00190.x | |
dc.identifier.issn | 02694727 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/106357 | |
dc.description.abstract | Objective: To assess the stability of captopril in different concentrations of invert sugar solution and to verify the hypothesis that the antioxidant effect of invert sugar can inhibit captopril's oxidative degradation. Method: Captopril 1 mg/ml formulations were prepared in 0% (Milli-Q water), 1%, 10%, 30% and 85% w/v of invert sugar and stored at 5°C. The formulations were sampled at intervals up to 30 days for assay of captopril using a stability-indicating high-performance liquid chromatographic method. Results: Captopril in formulations containing low concentrations (1%, 10%, 30% w/v) of invert sugar was significantly less stable than in the control formulation (captopril 1 mg/ml in Milli-Q water). In contrast, captopril in a formulation containing 85% w/v invert sugar was substantially more stable than in the control. Conclusion: Captopril formulated in a solution of 85% w/v invert sugar is stable for at least 2 weeks when stored at 5°C. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1046/j.1365-2710.1998.00190.x | |
dc.source | Scopus | |
dc.type | Article | |
dc.contributor.department | PHARMACY | |
dc.description.doi | 10.1046/j.1365-2710.1998.00190.x | |
dc.description.sourcetitle | Journal of Clinical Pharmacy and Therapeutics | |
dc.description.volume | 23 | |
dc.description.issue | 6 | |
dc.description.page | 451-456 | |
dc.description.coden | JCPTE | |
dc.identifier.isiut | 000078588900006 | |
Appears in Collections: | Staff Publications |
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