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Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.bbrc.2006.04.110
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dc.titlePim-1 kinase expression during murine mammary development
dc.contributor.authorGapter, L.A.
dc.contributor.authorMagnuson, N.S.
dc.contributor.authorNg, K.-y.
dc.contributor.authorHosick, H.L.
dc.date.accessioned2014-10-29T01:56:58Z
dc.date.available2014-10-29T01:56:58Z
dc.date.issued2006-07-07
dc.identifier.citationGapter, L.A., Magnuson, N.S., Ng, K.-y., Hosick, H.L. (2006-07-07). Pim-1 kinase expression during murine mammary development. Biochemical and Biophysical Research Communications 345 (3) : 989-997. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bbrc.2006.04.110
dc.identifier.issn0006291X
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/106222
dc.description.abstractPim-1 kinase phosphorylates substrates whose activities are linked to proliferation, survival, differentiation, and apoptosis. Although pim-1 is induced by hormones and cytokines, the hormonal control and contribution of Pim-1 to mammary gland development have not been evaluated. We examined Pim-1 expression in mammary cell lines, investigated whether Pim-1 levels could be altered in breast epithelia by mammogenic hormones, and evaluated Pim-1 expression during mammary development. We found that Pim-1 was elevated in most mammary carcinoma cell lines and progesterone increased Pim-1 protein to some extent in non-tumorigenic mammary epithelia. Pim-1 expression in situ was consistent with the documented profile of progesterone activity in mouse mammary glands. Pim-1 nuclear localization correlated with cytoplasmic distribution for its substrate, p21CIP/Waf1, and we found that Pim-1 and p21 associate in vitro. Our results suggest that Pim-1 expression may be regulated by progesterone during mammary development and Pim-1 associates with p21 in mammary epithelial cells. © 2006 Elsevier Inc. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.bbrc.2006.04.110
dc.sourceScopus
dc.subjectBreast
dc.subjectGrowth and development
dc.subjectKinase
dc.subjectMammary cell line
dc.subjectP21CIP/Waf1
dc.subjectPim-1
dc.subjectProgesterone
dc.typeArticle
dc.contributor.departmentPHARMACY
dc.description.doi10.1016/j.bbrc.2006.04.110
dc.description.sourcetitleBiochemical and Biophysical Research Communications
dc.description.volume345
dc.description.issue3
dc.description.page989-997
dc.description.codenBBRCA
dc.identifier.isiut000238346500014
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