Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.ejps.2008.01.007
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dc.titleModifying matrix micro-environmental pH to achieve sustained drug release from highly laminating alginate matrices
dc.contributor.authorChing, A.L.
dc.contributor.authorLiew, C.V.
dc.contributor.authorChan, L.W.
dc.contributor.authorHeng, P.W.S.
dc.date.accessioned2014-10-29T01:55:55Z
dc.date.available2014-10-29T01:55:55Z
dc.date.issued2008-04-23
dc.identifier.citationChing, A.L., Liew, C.V., Chan, L.W., Heng, P.W.S. (2008-04-23). Modifying matrix micro-environmental pH to achieve sustained drug release from highly laminating alginate matrices. European Journal of Pharmaceutical Sciences 33 (4-5) : 361-370. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ejps.2008.01.007
dc.identifier.issn09280987
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/106157
dc.description.abstractLamination of alginate matrix tablet at acidic pH can compromise its function as a sustained release carrier. This phenomenon is associated with the conversion of sodium alginate to alginic acid. An innovative approach for controlling the release of a highly water-soluble drug from such matrices is presented in this paper. Inclusion of pH-modifiers was employed to raise the micro-environmental pH within matrices undergoing dissolution at gastric pH. The changes in micro-environmental pH of hydrating alginate matrices were visualized with the aid of a pH-indicator and subsequently quantified using image analysis. Transient elevation in micro-environmental pH impeded alginate protonation and minimized or prevented matrix lamination, contributing to preservation of drug diffusion barrier. Significant reduction in the rate of drug release at pH 1.2 was achieved in the presence of such additives. The action of pH-modifiers was synergistically enhanced in the presence of a carbon dioxide barrier formed by effervescing sodium bicarbonate, reducing drug release in the acidic medium from 60 to 20%. Further insight into the influence of lamination on drug release from alginate compacts was given. © 2008 Elsevier B.V. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.ejps.2008.01.007
dc.sourceScopus
dc.subjectLamination
dc.subjectMicro-environmental pH
dc.subjectpH-sensitive polymer
dc.subjectSustained release
dc.typeArticle
dc.contributor.departmentPHARMACY
dc.description.doi10.1016/j.ejps.2008.01.007
dc.description.sourcetitleEuropean Journal of Pharmaceutical Sciences
dc.description.volume33
dc.description.issue4-5
dc.description.page361-370
dc.description.codenEPSCE
dc.identifier.isiut000255704200006
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