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Please use this identifier to cite or link to this item: https://doi.org/10.2174/187231207783221402
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dc.titleIn vitro metabolism of leflunomide by mouse and human liver microsomes.
dc.contributor.authorChan, E.C.
dc.contributor.authorNew, L.S.
dc.date.accessioned2014-10-29T01:54:07Z
dc.date.available2014-10-29T01:54:07Z
dc.date.issued2007-12
dc.identifier.citationChan, E.C.,New, L.S. (2007-12). In vitro metabolism of leflunomide by mouse and human liver microsomes.. Drug metabolism letters 1 (4) : 299-305. ScholarBank@NUS Repository. <a href="https://doi.org/10.2174/187231207783221402" target="_blank">https://doi.org/10.2174/187231207783221402</a>
dc.identifier.issn18723128
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/106039
dc.description.abstractLeflunomide was found to be metabolized predominantly to A77-1726 and two novel hydroxylated metabolites, M1 and M2, in microsomes while A77-1726 was only biotransformed to M1. M1 and M2 were proposed to be the hydroxylated alpha-cyanoenol form of A77-1726 and the hydroxylated 5 methyl-isoxazole form of leflunomide, respectively.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.2174/187231207783221402
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentPHARMACY
dc.description.doi10.2174/187231207783221402
dc.description.sourcetitleDrug metabolism letters
dc.description.volume1
dc.description.issue4
dc.description.page299-305
dc.identifier.isiutNOT_IN_WOS
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