Please use this identifier to cite or link to this item: https://doi.org/10.1002/pds.2234
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dc.titleDrug certainty-response in interview-based studies
dc.contributor.authorYau, W.-P.
dc.contributor.authorLin, K.J.
dc.contributor.authorWerler, M.M.
dc.contributor.authorLouik, C.
dc.contributor.authorMitchell, A.A.
dc.contributor.authorHernández-Díaz, S.
dc.date.accessioned2014-10-29T01:51:36Z
dc.date.available2014-10-29T01:51:36Z
dc.date.issued2011-11
dc.identifier.citationYau, W.-P., Lin, K.J., Werler, M.M., Louik, C., Mitchell, A.A., Hernández-Díaz, S. (2011-11). Drug certainty-response in interview-based studies. Pharmacoepidemiology and Drug Safety 20 (11) : 1210-1216. ScholarBank@NUS Repository. https://doi.org/10.1002/pds.2234
dc.identifier.issn10538569
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/105851
dc.description.abstractPurpose: Imperfect recall of exposure timing challenges the ascertainment of medications in interview-based studies. Methods: We propose an algorithm to classify medication exposure, taking into account recall certainty. The availability of medication use details, including duration of use, start and stop dates, and maternal estimates of how certain they were about these dates, allowed classification of subjects as either likely or possibly exposed in the first trimester of pregnancy. We applied the algorithm to study an association between prenatal tetracycline exposure and risk of congenital heart defects previously reported by the National Birth Defects Prevention Study, using 1993-2008 data from 11517 subjects in the Slone Epidemiology Center Birth Defects Study. Results: Among women exposed to tetracyclines during pregnancy (n=58), 50% and 19% were likely and possibly exposed, respectively, in the first trimester, and 31% were exposed outside the first trimester. Compared with non-use during pregnancy, the crude OR for exposure outside the first trimester was 1.0 (95%CI 0.4-2.5), and that for exposed (likely or possibly, combined) in the first trimester was 1.7 (95%CI 0.9-3.2); however, the ORs based on the algorithms were 0.9 (95%CI 0.3-3.0) for possibly exposed and 2.2 (95%CI 1.0-4.6) for likely exposed. Conclusions: A "certainty-response" (stronger association with higher level of certainty) was found within exposures in the window of etiological interest. Algorithms for exposure classification that incorporate recall certainty may be useful in interview-based studies. © 2011 John Wiley & Sons, Ltd.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/pds.2234
dc.sourceScopus
dc.subjectAlgorithms
dc.subjectEpidemiologic methods
dc.subjectInterviews as topic
dc.subjectMaternal exposure
dc.subjectQuestionnaires
dc.subjectUncertainty
dc.typeArticle
dc.contributor.departmentPHARMACY
dc.description.doi10.1002/pds.2234
dc.description.sourcetitlePharmacoepidemiology and Drug Safety
dc.description.volume20
dc.description.issue11
dc.description.page1210-1216
dc.description.codenPDSAE
dc.identifier.isiut000296974300011
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