Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/105773
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dc.titleConformational and structural features determining in vitro antimalarial activity in some indolo[3,2-c]quinolines, anilinoquinolines and tetrahydroindolo[3,2-d]benzazepines
dc.contributor.authorKoh, H.
dc.contributor.authorGo, M.
dc.contributor.authorNgiam, T.
dc.contributor.authorMak, J.
dc.date.accessioned2014-10-29T01:50:33Z
dc.date.available2014-10-29T01:50:33Z
dc.date.issued1994
dc.identifier.citationKoh, H.,Go, M.,Ngiam, T.,Mak, J. (1994). Conformational and structural features determining in vitro antimalarial activity in some indolo[3,2-c]quinolines, anilinoquinolines and tetrahydroindolo[3,2-d]benzazepines. European Journal of Medicinal Chemistry 29 (2) : 107-113. ScholarBank@NUS Repository.
dc.identifier.issn02235234
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/105773
dc.description.abstractA series of indolo[3,2-c]quinolines, anilinoquinolines and tetrahydroindolo[3,2-d]benzazepines, which differ in the conformational planarity of the key nuclei and the distance (N...N+) between the ring and side-chain nitrogen atoms, have been synthesized and evaluated in vitro against a number of isolates of Plasmodium falciparum. The results show that differences in conformational planarity of the indolo[3,2-c]quinoline (rigid), anilinoquinoline (flexible) and tetrahydroindolo[3,2-d]benzazepine (semi-rigid) nuclei have little effect on activity. However, the N...N+ distance is an important determinant of activity and analogues with a distance comparable to the N...N+ distance of amodiaquine and chloroquine demonstrated antimalarial activity. © 1994.
dc.sourceScopus
dc.subjectanilinoquinoline
dc.subjectantimalarial activity
dc.subjectindolo[3,2-c]quinoline
dc.subjectSAR
dc.subjecttetrahydroindolo[3,2-d]benzazepine
dc.typeArticle
dc.contributor.departmentPHARMACY
dc.description.sourcetitleEuropean Journal of Medicinal Chemistry
dc.description.volume29
dc.description.issue2
dc.description.page107-113
dc.description.codenEJMCA
dc.identifier.isiutNOT_IN_WOS
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