Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/105758
DC FieldValue
dc.titleComparison of the effects of mefloquine and ryanodine on the directly stimulated rat hemidiaphragm preparation
dc.contributor.authorLee, H.S.
dc.contributor.authorGo, M.L.
dc.date.accessioned2014-10-29T01:50:23Z
dc.date.available2014-10-29T01:50:23Z
dc.date.issued1993
dc.identifier.citationLee, H.S.,Go, M.L. (1993). Comparison of the effects of mefloquine and ryanodine on the directly stimulated rat hemidiaphragm preparation. Archives Internationales de Pharmacodynamie et de Therapie 321 : 81-91. ScholarBank@NUS Repository.
dc.identifier.issn00039780
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/105758
dc.description.abstractThe effects of the antimalarial agent mefloquine on directly stimulated rat hemidiaphragm were investigated after nerve transmission had been blocked with α-bungarotoxin. Mefloquine (50 and 75 μM) caused contractures and diminished directly stimulated twitch responses. The mefloquine-induced contracture was significantly diminished in low Ca2+ Krebs-Henseleit solution and after pretreatment with phospholipase C. It was potentiated following an initial exposure to ryanodine. Mefloquine, as well as ryanodine, reduced the caffeine contractures obtained in low Ca2+ media. The results suggest that Ca2+-induced Ca2+ release, involving the action of mefloquine on some phospholipid component of the sarcolemma, appears to be important in the initiation of the contracture. The loss in caffeine response following pretreatment with mefloquine indicates that mefloquine also causes depletion of Ca2+ from sarcoplasmic reticulum stores.
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentPHARMACY
dc.description.sourcetitleArchives Internationales de Pharmacodynamie et de Therapie
dc.description.volume321
dc.description.page81-91
dc.description.codenAIPTA
dc.identifier.isiutNOT_IN_WOS
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.