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Please use this identifier to cite or link to this item: https://doi.org/10.1007/s11095-009-9865-7
DC FieldValue
dc.titleComparing the relative oxidative DNA damage caused by various arsenic species by quantifying urinary levels of 8-hydroxy-2′-deoxyguanosine with isotope-dilution liquid chromatography/mass spectrometry
dc.contributor.authorWu, J.-Z.
dc.contributor.authorHo, P.C.
dc.date.accessioned2014-10-29T01:50:10Z
dc.date.available2014-10-29T01:50:10Z
dc.date.issued2009-06
dc.identifier.citationWu, J.-Z., Ho, P.C. (2009-06). Comparing the relative oxidative DNA damage caused by various arsenic species by quantifying urinary levels of 8-hydroxy-2′-deoxyguanosine with isotope-dilution liquid chromatography/mass spectrometry. Pharmaceutical Research 26 (6) : 1525-1533. ScholarBank@NUS Repository. https://doi.org/10.1007/s11095-009-9865-7
dc.identifier.issn07248741
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/105754
dc.description.abstractPurpose: To investigate the association between various arsenicals and the potential oxidative stress caused, we examined the urinary levels of 8-hydroxy-2′-deoxyguanosine (8-OH-dGuo), a biomarker of oxidative DNA damage in rats after daily oral administration of arsenic trioxide/arsenite (As2O3), realgar (α-As4S4) and orpiment (As2S3) over 14 days and compared the levels with control rats. Methods: 8-OH-dGuo in urine was quantified with isotope-dilution liquid chromatography coupled with tandem mass spectrometry (LC/MS/MS) after sample cleaning with solid phase extraction (SPE). Urinary arsenic concentrations were measured by graphite furnace atomic absorption spectrometry (GFAAS). Results: All arsenicals caused elevated urinary 8-OH-dGuo excretion in rats from day 1 after oral administration (p∈
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1007/s11095-009-9865-7
dc.sourceScopus
dc.subject8-hydroxy-2′- deoxyguanosine
dc.subjectArsenite
dc.subjectOrpiment
dc.subjectOxidative DNA damage
dc.subjectRealgar
dc.typeArticle
dc.contributor.departmentPHARMACY
dc.description.doi10.1007/s11095-009-9865-7
dc.description.sourcetitlePharmaceutical Research
dc.description.volume26
dc.description.issue6
dc.description.page1525-1533
dc.description.codenPHREE
dc.identifier.isiut000265834600023
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