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Title: Classification of annular bed flow patterns and investigation on their influence on the bottom spray fluid bed coating process
Authors: Wang, L.K.
Heng, P.W.S. 
Liew, C.V. 
Keywords: Annular bed flow pattern
Bottom spray fluid bed coating
Coat uniformity
Particle image velocimetry
Process analytical technology
Issue Date: May-2010
Citation: Wang, L.K., Heng, P.W.S., Liew, C.V. (2010-05). Classification of annular bed flow patterns and investigation on their influence on the bottom spray fluid bed coating process. Pharmaceutical Research 27 (5) : 756-766. ScholarBank@NUS Repository.
Abstract: Purpose. This study aims to classify annular bed flow patterns in the bottom spray fluid, bed coating process, study their influence on coat uniformity and investigate the feasibility of developing real-time annular bed flow pattern detection as a PAT tool. Methods. High-speed imaging and particle image velocimetry were used to visualize annular bed flow. Color coating and subsequent tristimulus colorimetry were employed to determine influence of annular bed flow pattern on coat uniformity. Feasibility of monitoring annular bed flow pattern through an observation, window was tested using miniaturized particle velocity field and time series particle velocity orientation information. Results. Three types of annular bed flow patterns were identified. Plug flow gave the best coat uniformity followed, by global and localized, fluidization. Plug flow may be advantageous for high spray-rate conditions, large-scale coating and prevention of particle segregation. Plug flow could be differentiated from the other flow patterns through a simulated observation window. Conclusion. Annular bed flow patterns were classified and found to influence particle coat uniformity noticeably. Availability of annular bed flow information for large-scale coaters would enable adjustments for process optimization. This study highlights the potential of monitoring annular bed flow pattern, as a PAT tool. © 2010 Springer Science+Business Media, LLC.
Source Title: Pharmaceutical Research
ISSN: 07248741
DOI: 10.1007/s11095-009-0046-5
Appears in Collections:Staff Publications

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