Please use this identifier to cite or link to this item: https://doi.org/10.1002/lpor.201200059
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dc.titleAdvances in fluorescence diagnosis to track footprints of cancer progression in vivo
dc.contributor.authorOlivo, M.
dc.contributor.authorHo, C.J.H.
dc.contributor.authorFu, C.Y.
dc.date.accessioned2014-10-29T01:48:15Z
dc.date.available2014-10-29T01:48:15Z
dc.date.issued2013-09
dc.identifier.citationOlivo, M., Ho, C.J.H., Fu, C.Y. (2013-09). Advances in fluorescence diagnosis to track footprints of cancer progression in vivo. Laser and Photonics Reviews 7 (5) : 646-662. ScholarBank@NUS Repository. https://doi.org/10.1002/lpor.201200059
dc.identifier.issn18638880
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/105623
dc.description.abstractFluorescence spectroscopy and imaging have been widely used for in vivo cancer diagnosis and therapy monitoring in preclinical models, as well as clinical translation. Great attempts have been made to develop novel fluorescence techniques and improve on existing ones, which can now be used in conjunction with newly developed fluorescent probes for specific cancer imaging. In this review, a broad overview of fluorescence techniques is provided, including photodynamic diagnosis, laser confocal endomicroscopy and fluorescence lifetime imaging, coupled with endogenous and exogenous fluorophores. In particular, endogenous fluorophores, such as nicotinamide adenine dinucleotide (NADH) and flavin adenine dinucleotide (FAD), are highlighted as they are linked to cellular metabolism in precancer growth. The use of near-infrared dyes, such as indocynanine green (ICG), for imaging deep-tissue regions is also reviewed. In addition, diagnostic algorithms used for tissue classification and cancer detection will be discussed. Lastly, emerging technologies in fluorescence diagnosis will also be included. © 2013 by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/lpor.201200059
dc.sourceScopus
dc.subjectBiomarkers
dc.subjectCancer
dc.subjectDiagnostics
dc.subjectFluorescence correlation spectroscopy
dc.subjectFluorescence lifetime
dc.subjectFluorescence spectroscopy and imaging
dc.subjectIn vivo
dc.subjectMolecular imaging
dc.subjectNanoparticle probes
dc.subjectPhotodynamic diagnosis
dc.subjectTomography
dc.typeArticle
dc.contributor.departmentPHARMACY
dc.description.doi10.1002/lpor.201200059
dc.description.sourcetitleLaser and Photonics Reviews
dc.description.volume7
dc.description.issue5
dc.description.page646-662
dc.identifier.isiut000326093800009
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