Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.tetlet.2009.07.113
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dc.titleA new synthesis of 2,8-disubstituted pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines
dc.contributor.authorDolzhenko, A.V.
dc.contributor.authorPastorin, G.
dc.contributor.authorDolzhenko, A.V.
dc.contributor.authorChui, W.K.
dc.date.accessioned2014-10-29T01:47:29Z
dc.date.available2014-10-29T01:47:29Z
dc.date.issued2009-10-07
dc.identifier.citationDolzhenko, A.V., Pastorin, G., Dolzhenko, A.V., Chui, W.K. (2009-10-07). A new synthesis of 2,8-disubstituted pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines. Tetrahedron Letters 50 (40) : 5617-5621. ScholarBank@NUS Repository. https://doi.org/10.1016/j.tetlet.2009.07.113
dc.identifier.issn00404039
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/105575
dc.description.abstractA practical synthesis of pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines, which are key intermediates in the preparation of adenosine receptor antagonists, is developed. The method allows introduction of a variety of aryl substituents at position 2 of the pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine system via cyclocondensation of 5-amino-4-iminopyrazolo[3,4-d]pyrimidine with benzaldehydes accompanied with oxidation by iodobenzene diacetate. Some unexpected reactions are observed and the structures of the products are confirmed using NMR spectroscopy and X-ray crystallography. © 2009 Elsevier Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.tetlet.2009.07.113
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentPHARMACY
dc.description.doi10.1016/j.tetlet.2009.07.113
dc.description.sourcetitleTetrahedron Letters
dc.description.volume50
dc.description.issue40
dc.description.page5617-5621
dc.description.codenTELEA
dc.identifier.isiut000269715600018
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