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https://doi.org/10.1093/annonc/mdl084
Title: | A multicentre randomised phase II study of carboplatin in combination with gemcitabine at standard rate or fixed dose rate infusion in patients with advanced stage non-small-cell lung cancer | Authors: | Soo, R.A. Wang, L.Z. Tham, L.S. Yong, W.P. Boyer, M. Lim, H.L. Lee, H.S. Millward, M. Liang, S. Beale, P. Lee, S.C. Goh, B.C. |
Keywords: | Gemcitabine Non-small cell lung cancer Pharmacokinetics |
Issue Date: | Jul-2006 | Citation: | Soo, R.A., Wang, L.Z., Tham, L.S., Yong, W.P., Boyer, M., Lim, H.L., Lee, H.S., Millward, M., Liang, S., Beale, P., Lee, S.C., Goh, B.C. (2006-07). A multicentre randomised phase II study of carboplatin in combination with gemcitabine at standard rate or fixed dose rate infusion in patients with advanced stage non-small-cell lung cancer. Annals of Oncology 17 (7) : 1128-1133. ScholarBank@NUS Repository. https://doi.org/10.1093/annonc/mdl084 | Abstract: | Background: Intracellular gemcitabine triphosphate (dFdCTP) levels can be optimised by administering gemcitabine at a fixed dose rate infusion. Patients and methods: Patients with chemonaive advanced non-small cell lung cancer (NSCLC) were randomised to receive gemcitabine at a fixed dose rate gemcitabine 750 mg/m2 over 75 min (arm A) or gemcitabine 1000 mg/m2 over 30 min (arm B) on days 1 and 8 every three week cycle. Carboplatin at AUC of 5 was administered in both treatment arms on day 1 of each cycle. End points were activity, tolerability and pharmacokinetics of plasma and intracellular gemcitabine. Results: 76 patients were randomised. Response rate was 34 % in arm A and 42% in arm B. Toxicity and quality of life scores were similar for both treatment arms. Mean plasma Cmax gemcitabine and mean dFdCTP AUC in arm A was 20.8 μM ± 17.2 μM and 35 079 ± 18 216 μM*min respectively and in arm B, 41.2 ± 13.9 μM and 32 249 ± 11 267 μM*min respectively. dFdCTP saturation was reached in Arm B but not in Arm A. Conclusion: The saturability of dFdCTP accumulation in Arm A suggests optimal delivery of gemcitabine is achieved using fixed rate infusion compared to 30-min infusion. Fixed dose rate gemcitabine is active and feasible, supporting the concept of fixed dosing rate of gemcitabine in advanced NSCLC. However, this entails a longer infusion time with associated higher costs involved. © 2006 European Society for Medical Oncology. | Source Title: | Annals of Oncology | URI: | http://scholarbank.nus.edu.sg/handle/10635/105570 | ISSN: | 09237534 | DOI: | 10.1093/annonc/mdl084 |
Appears in Collections: | Staff Publications |
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