1,2,4-triazolo[1,5-a][1,3,5]triazines (5-azapurines): synthesis and biological activity

Abstract

The present review gives an account of the various synthetic routes to the 5-aza-analogue of purine-1,2,4-triazolo[1,5-a][1,3,5]triazine nucleus and polyfused systems bearing this heterocyclic core. Data concerning biological activity of the compounds with 1,2,4-triazolo[1,5-a][1,3,5]triazine skeleton are also discussed.{A figure is presented}. © 2006 The Japan Institute of Heterocyclic Chemistry.