Discretization approach and nonparametric modeling for long-term HIV dynamic model

Abstract

Modeling viral load response in long-term HIV dynamics is important for AIDS clinical study. It allows one to examine how a patient recuperates for an antiviral treatment. This paper investigates a discretization approach to the viral load based on a long-term HIV dynamic model. We propose a two-stage nonparametric procedure for estimating the viral load and the time-varying new productive virus. Simulation study shows that the proposed estimated methods are efficient and powerful for fitting long-term viral load measurements. © Springer-Verlag Berlin Heidelberg 2005.