Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.tibs.2011.07.001
DC FieldValue
dc.titleProlyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteins
dc.contributor.authorLiou, Y.-C.
dc.contributor.authorZhou, X.Z.
dc.contributor.authorLu, K.P.
dc.date.accessioned2014-10-27T08:49:02Z
dc.date.available2014-10-27T08:49:02Z
dc.date.issued2011-10
dc.identifier.citationLiou, Y.-C., Zhou, X.Z., Lu, K.P. (2011-10). Prolyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteins. Trends in Biochemical Sciences 36 (10) : 501-514. ScholarBank@NUS Repository. https://doi.org/10.1016/j.tibs.2011.07.001
dc.identifier.issn09680004
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/102515
dc.description.abstractPin1 is a highly conserved enzyme that only isomerizes specific phosphorylated Ser/Thr-Pro bonds in certain proteins, thereby inducing conformational changes. Such conformational changes represent a novel and tightly controlled signaling mechanism regulating a spectrum of protein activities in physiology and disease; often through phosphorylation-dependent, ubiquitin-mediated proteasomal degradation. In this review, we summarize recent advances in elucidating the role and regulation of Pin1 in controlling protein stability. We also propose a mechanism by which Pin1 functions as a molecular switch to control the fates of phosphoproteins. We finally stress the need to develop tools to visualize directly Pin1-catalyzed protein conformational changes as a way to determine their roles in the development and treatment of human diseases. © 2011 Elsevier Ltd.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.tibs.2011.07.001
dc.sourceScopus
dc.typeReview
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.description.doi10.1016/j.tibs.2011.07.001
dc.description.sourcetitleTrends in Biochemical Sciences
dc.description.volume36
dc.description.issue10
dc.description.page501-514
dc.description.codenTBSCD
dc.identifier.isiut000296118800001
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