Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.stem.2009.03.005
DC FieldValue
dc.titleMolecules that Promote or Enhance Reprogramming of Somatic Cells to Induced Pluripotent Stem Cells
dc.contributor.authorFeng, B.
dc.contributor.authorNg, J.-H.
dc.contributor.authorHeng, J.-C.D.
dc.contributor.authorNg, H.-H.
dc.date.accessioned2014-10-27T08:48:48Z
dc.date.available2014-10-27T08:48:48Z
dc.date.issued2009-04-03
dc.identifier.citationFeng, B., Ng, J.-H., Heng, J.-C.D., Ng, H.-H. (2009-04-03). Molecules that Promote or Enhance Reprogramming of Somatic Cells to Induced Pluripotent Stem Cells. Cell Stem Cell 4 (4) : 301-312. ScholarBank@NUS Repository. https://doi.org/10.1016/j.stem.2009.03.005
dc.identifier.issn19345909
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/102494
dc.description.abstractReprogramming of somatic cells to induced pluripotent stem cells (iPSCs) can be achieved by viral-mediated transduction of defined transcription factors. Moving toward the eventual goal of clinical application, it is necessary to overcome limitations such as low reprogramming efficiency and genomic alterations due to viral integration. Here, we review recent progress made in the usage of genetic factors, chemical inhibitors, and signaling molecules that can either replace core reprogramming factors or enhance reprogramming efficiency. Current iPSC studies will provide a paradigm for the combinatorial use of genetic factors and chemicals for the broader applications to alter cellular states of potency. © 2009 Elsevier Inc. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.stem.2009.03.005
dc.sourceScopus
dc.typeReview
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.description.doi10.1016/j.stem.2009.03.005
dc.description.sourcetitleCell Stem Cell
dc.description.volume4
dc.description.issue4
dc.description.page301-312
dc.identifier.isiut000265162700007
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