Drug ADME-associated protein database as a resource for facilitating pharmacogenomics research

Abstract

Increasing effort and interest have been directed at pharmacogenomics for elucidating the mechanism of individual differences in drug response and the design of personalized drugs and dosages. Knowledge about drug absorption, distribution, metabolism, and excretion (ADME) proteins and drug targets is useful for facilitating the search and evaluation of polymorphisms and other pharmacogenomic-contributing factors. A database of drug ADME-associated proteins, at http://bidd.nus.edu.sg/group/ admeap/admeap.asp, serves as a resource for comprehensive information about proteins potentially responsible for pharmacogenetic effects of pharmacokinetic origin. This database currently contains entries for 316 ADME-associated proteins, 1,070 substrates and inhibitors, 1,337 known polymorphisms in 121 proteins, and 327 drugs reported to have altered responses linked to an ADME-associated protein. It also provides physiological function of each protein, pharmacokinetic effect, ADME classification, direction, and driving force of disposition, location and tissue distribution, synonyms, and gene name. Information in this database and its usefulness for facilitating pharmacogenomic research is discussed. © 2004 Wiley-Liss, Inc.