Please use this identifier to cite or link to this item: https://doi.org/10.2174/1389202043489944
DC FieldValue
dc.titleCurrent genome-wide analysis on serine proteases in innate immunity
dc.contributor.authorDing, J.L.
dc.contributor.authorWang, L.
dc.contributor.authorHo, B.
dc.date.accessioned2014-10-27T08:48:04Z
dc.date.available2014-10-27T08:48:04Z
dc.date.issued2004-02
dc.identifier.citationDing, J.L.,Wang, L.,Ho, B. (2004-02). Current genome-wide analysis on serine proteases in innate immunity. Current Genomics 5 (2) : 147-155. ScholarBank@NUS Repository. <a href="https://doi.org/10.2174/1389202043489944" target="_blank">https://doi.org/10.2174/1389202043489944</a>
dc.identifier.issn13892029
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/102429
dc.description.abstractRecent studies on host defense against microbial pathogens have demonstrated that innate immunity predated adaptive immune response. Present in all multicellular organisms, the innate defense uses genome-encoded receptors, to distinguish self from non-self. The invertebrate innate immune system employs several mechanisms to recognize and eliminate pathogens: (i) blood coagulation to immobilize the invading microbes, (ii) lectin-induced complement pathway to lyse and opsonize the pathogen, (iii) melanization to oxidatively kill invading microorganisms and (iv) prompt synthesis of potent effectors, such as antimicrobial peptides. Serine proteases play significant roles in these mechanisms, although studies on their functions remain fragmentary, and only several members have been characterized, for example, the serine protease cascade in Drosophila dorsoventral patterning; the Limulus blood clotting cascade; and the silk worm prophenoloxidase cascade. Additionally, serine proteases are involved in processing Späetzle, the Toll ligand for signaling in antimicrobial peptide synthesis. The recent completion of the Drosophila and Anopheles genomes offers a tantalizing promise for genomic analysis of innate immunity of invertebrates. In this review, we discuss the latest genome-wide studies conducted in invertebrates with emphasis on serine proteases involved in innate immune response. We seek to clarify the analysis by using empirical research data on these proteases via classical approaches in biochemical, molecular and genetic methods. We provide an update on the serine protease cascades in various invertebrates and map a relationship between their involvement in early embryonic development, blood coagulation and innate immune defense. © 2004 Bentham Science Publishers Ltd.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.2174/1389202043489944
dc.sourceScopus
dc.subjectDNA microarray
dc.subjectEmpirical approaches
dc.subjectGenomics
dc.subjectInnate immunity
dc.subjectProteolytic cascades
dc.subjectSerine proteases
dc.typeReview
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.description.doi10.2174/1389202043489944
dc.description.sourcetitleCurrent Genomics
dc.description.volume5
dc.description.issue2
dc.description.page147-155
dc.description.codenCGUEA
dc.identifier.isiutNOT_IN_WOS
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

3
checked on Oct 14, 2020

Page view(s)

101
checked on Oct 10, 2020

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.