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Title: Baculovirus: An insect-derived vector for diverse gene transfer applications
Authors: Airenne, K.J.
Hu, Y.-C.
Kost, T.A.
Smith, R.H.
Kotin, R.M.
Ono, C.
Matsuura, Y.
Wang, S. 
Ylä-Herttuala, S.
Issue Date: Apr-2013
Citation: Airenne, K.J., Hu, Y.-C., Kost, T.A., Smith, R.H., Kotin, R.M., Ono, C., Matsuura, Y., Wang, S., Ylä-Herttuala, S. (2013-04). Baculovirus: An insect-derived vector for diverse gene transfer applications. Molecular Therapy 21 (4) : 739-749. ScholarBank@NUS Repository.
Abstract: Insect-derived baculoviruses have emerged as versatile and safe workhorses of biotechnology. Baculovirus expression vectors (BEVs) have been applied widely for crop and forest protection, as well as safe tools for recombinant protein production in insect cells. However, BEVs ability to efficiently transduce noninsect cells is still relatively poorly recognized despite the fact that efficient baculovirus-mediated in vitro and ex vivo gene delivery into dormant and dividing vertebrate cells of diverse origin has been described convincingly by many authors. Preliminary proof of therapeutic potential has also been established in preclinical studies. This review summarizes the advantages and current status of baculovirus-mediated gene delivery. Stem cell transduction, preclinical animal studies, tissue engineering, vaccination, cancer gene therapy, viral vector production, and drug discovery are covered. © The American Society of Gene & Cell Therapy.
Source Title: Molecular Therapy
ISSN: 15250016
DOI: 10.1038/mt.2012.286
Appears in Collections:Staff Publications

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