Please use this identifier to cite or link to this item:
|Title:||Zebrafish id2 developmental expression pattern contains evolutionary conserved and species-specific characteristics||Authors:||Chong, S.-W.
Corpuscles of Stannius
|Issue Date:||Dec-2005||Citation:||Chong, S.-W., Nguyen, T.-T.-H., Chu, L.-T., Jiang, Y.-J., Korzh, V. (2005-12). Zebrafish id2 developmental expression pattern contains evolutionary conserved and species-specific characteristics. Developmental Dynamics 234 (4) : 1055-1063. ScholarBank@NUS Repository. https://doi.org/10.1002/dvdy.20625||Abstract:||The inhibitor of differentiation or inhibitor of DNA binding (Id) family are members of the helix-loop-helix (HLH) group of transcription factors that play important roles in cell proliferation, differentiation, cell cycle control, and apoptosis. They modulate the formation of active class A-class B basic HLH (bHLH) complexes. Ids lack the amino-terminal associated basic region necessary for DNA binding, thus sequestering the class A factors, inhibiting the formation of active class A-class B heterodimers and, therefore, are considered to act as dominant-negative regulators of differentiation pathways. We isolated zebrafish id2, and its expression during development was characterized. id2, in addition to regions of expression detected in Xenopus and mice, is also expressed in the tegmentum; midbrain-hindbrain boundary; cerebellum; rhombomeres 2,3,4,6; notochord; and corpuscles of Stannius. Furthermore, we show that expression of id2 is repressed in mind bomb mutants, suggesting a role of Notch upstream of Id2. © 2005 Wiley-Liss, Inc.||Source Title:||Developmental Dynamics||URI:||http://scholarbank.nus.edu.sg/handle/10635/102180||ISSN:||10588388||DOI:||10.1002/dvdy.20625|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Mar 4, 2021
WEB OF SCIENCETM
checked on Feb 24, 2021
checked on Feb 28, 2021
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.