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Title: The JAK/STAT pathway positively regulates DPP signaling in the Drosophila germline stem cell niche
Authors: Wang, L.
Li, Z.
Cai, Y. 
Issue Date: 25-Feb-2008
Citation: Wang, L., Li, Z., Cai, Y. (2008-02-25). The JAK/STAT pathway positively regulates DPP signaling in the Drosophila germline stem cell niche. Journal of Cell Biology 180 (4) : 721-728. ScholarBank@NUS Repository.
Abstract: The stem cell niche, formed by surrounding stromal cells, provides extrinsic signals that maintain stem cell self-renewal. However, it remains unclear how these extrinsic signals are regulated. In the Drosophila female germline stem cell (GSC) niche, Decapentaplegic (DPP) is an important niche factor for GSC self-renewal. The exact source of the DPP and how its transcription is regulated in this niche remain unclear. We show that dpp is expressed in somatic cells of the niche including the cap cells, a subtype of niche cells. Furthermore, our data show that the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway positively regulates dpp expression in the cap cells, suggesting that JAK/STAT activity is required in somatic niche cells to prevent precocious GSC differentiation. Our data suggest that the JAK/STAT pathway functions downstream/independently of cap cell formation induced by Notch signaling. JAK/STAT signaling may also regulate dpp expression in the male GSC niche, suggesting a common origin of female and male GSC niches. © The Rockefeller University Press.
Source Title: Journal of Cell Biology
ISSN: 00219525
DOI: 10.1083/jcb.200711022
Appears in Collections:Staff Publications

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