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|Title:||Synergistic effects of nuclear factors - GATA, VBP and ER in potentiating vitellogenin gene transcription||Authors:||Teo, B.Y.
Imperfect estrogen response element
Vitellogenin binding protein
Vitellogenin gene promoter
|Issue Date:||1-Oct-1999||Citation:||Teo, B.Y., Tan, N.S., Lam, T.J., Ding, J.L. (1999-10-01). Synergistic effects of nuclear factors - GATA, VBP and ER in potentiating vitellogenin gene transcription. FEBS Letters 459 (1) : 57-63. ScholarBank@NUS Repository. https://doi.org/10.1016/S0014-5793(99)01212-0||Abstract:||The Oreochromis aureus vitellogenin (OaVtg) gene contains three imperfect oestrogen response elements (EREs) and GATA and VBP (vitellogenin binding protein) binding sites. An analysis of the promoter indicates that the 5'-flanking region up to position -625 is sufficient to mediate E2 control. Furthermore, transfection of deletion and mutagenised promoters indicates that both GATA and VBP synergise with ER, and thus contribute to the regulation of the endogenous OaVtg gene. These findings support the notion that the interplay of promoter elements mediates proper hormone-dependent and tissue-specific expression of the OaVtg gene, regardless of non-consensus sequence context of EREs and VBP. Copyright (C) 1999 Federation of European Biochemical Societies.||Source Title:||FEBS Letters||URI:||http://scholarbank.nus.edu.sg/handle/10635/101793||ISSN:||00145793||DOI:||10.1016/S0014-5793(99)01212-0|
|Appears in Collections:||Staff Publications|
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