Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0014-5793(99)01212-0
Title: Synergistic effects of nuclear factors - GATA, VBP and ER in potentiating vitellogenin gene transcription
Authors: Teo, B.Y. 
Tan, N.S. 
Lam, T.J. 
Ding, J.L. 
Keywords: Estrogen receptor
GATA
Imperfect estrogen response element
Oreochromis aureus
Vitellogenin binding protein
Vitellogenin gene promoter
Issue Date: 1-Oct-1999
Citation: Teo, B.Y., Tan, N.S., Lam, T.J., Ding, J.L. (1999-10-01). Synergistic effects of nuclear factors - GATA, VBP and ER in potentiating vitellogenin gene transcription. FEBS Letters 459 (1) : 57-63. ScholarBank@NUS Repository. https://doi.org/10.1016/S0014-5793(99)01212-0
Abstract: The Oreochromis aureus vitellogenin (OaVtg) gene contains three imperfect oestrogen response elements (EREs) and GATA and VBP (vitellogenin binding protein) binding sites. An analysis of the promoter indicates that the 5'-flanking region up to position -625 is sufficient to mediate E2 control. Furthermore, transfection of deletion and mutagenised promoters indicates that both GATA and VBP synergise with ER, and thus contribute to the regulation of the endogenous OaVtg gene. These findings support the notion that the interplay of promoter elements mediates proper hormone-dependent and tissue-specific expression of the OaVtg gene, regardless of non-consensus sequence context of EREs and VBP. Copyright (C) 1999 Federation of European Biochemical Societies.
Source Title: FEBS Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/101793
ISSN: 00145793
DOI: 10.1016/S0014-5793(99)01212-0
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

9
checked on Jul 13, 2019

WEB OF SCIENCETM
Citations

10
checked on Jul 13, 2019

Page view(s)

58
checked on May 24, 2019

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.