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Please use this identifier to cite or link to this item: https://doi.org/10.1021/jm901469p
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dc.titleStructural insights into the design of small molecule inhibitors that selectively antagonize Mcl-1
dc.contributor.authorBernardo, P.H.
dc.contributor.authorSivaraman, T.
dc.contributor.authorWan, K.-F.
dc.contributor.authorXu, J.
dc.contributor.authorKrishnamoorthy, J.
dc.contributor.authorSons, C.M.
dc.contributor.authorTian, L.
dc.contributor.authorChin, J.S.F.
dc.contributor.authorLim, D.S.W.
dc.contributor.authorMok, H.Y.K.
dc.contributor.authorYu, V.C.
dc.contributor.authorTong, J.C.
dc.contributor.authorChai, C.L.L.
dc.date.accessioned2014-10-27T08:40:45Z
dc.date.available2014-10-27T08:40:45Z
dc.date.issued2010-03-11
dc.identifier.citationBernardo, P.H., Sivaraman, T., Wan, K.-F., Xu, J., Krishnamoorthy, J., Sons, C.M., Tian, L., Chin, J.S.F., Lim, D.S.W., Mok, H.Y.K., Yu, V.C., Tong, J.C., Chai, C.L.L. (2010-03-11). Structural insights into the design of small molecule inhibitors that selectively antagonize Mcl-1. Journal of Medicinal Chemistry 53 (5) : 2314-2318. ScholarBank@NUS Repository. https://doi.org/10.1021/jm901469p
dc.identifier.issn00222623
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/101765
dc.description.abstractThe screening of a small focused library of rhodanine derivatives as inhibitors of Bcl-2 proteins led to the discovery of two structurally related compounds with different binding profiles against the Bcl-XL and the Mcl-1 proteins. Subsequent NMR studies with mutant proteins and in silico docking studies provide a possible rationale for the observed specificity. © 2010 American Chemical Society.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1021/jm901469p
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.contributor.departmentPHARMACY
dc.description.doi10.1021/jm901469p
dc.description.sourcetitleJournal of Medicinal Chemistry
dc.description.volume53
dc.description.issue5
dc.description.page2314-2318
dc.description.codenJMCMA
dc.identifier.isiut000275087000037
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