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|Title:||Seasonal variation in respiratory syncytial virus chest infection in the tropics||Authors:||Chan, P.W.K.
Respiratory syncytial virus
|Issue Date:||2002||Citation:||Chan, P.W.K., Chew, F.T., Tan, T.N., Chua, K.B., Hooi, P.S. (2002). Seasonal variation in respiratory syncytial virus chest infection in the tropics. Pediatric Pulmonology 34 (1) : 47-51. ScholarBank@NUS Repository. https://doi.org/10.1002/ppul.10095||Abstract:||Respiratory syncytial virus (RSV) is the most important cause of lower respiratory tract infection (LRTI) in young children. We determined if there was a seasonal variation in Malaysia in the incidence of RSV infection in young children admitted with LRTI, and possible associations of RSV infection with local meteorological parameters. A total of 5,691 children, aged less than 24 months and hospitalized with LRTI (i.e., bronchiolitis and pneumonia) between 1982-1997, were included in this study. Nasopharyngeal samples were collected and examined for RSV by immunofluorescence, viral culture, or both. Seasonal variations were determined by analyzing the monthly RSV-positive isolation rate via time series analysis. Possible correlations with local meteorological parameters were also evaluated. RSV was isolated in 1,047 (18.4%) children. Seasonal variations in RSV infection rate were evident and peaked during the months of November, December, and January (test statistics [T] = 53.7, P < 0.001). This seasonal variation was evident for both bronchiolitis and pneumonia categories (T = 42.8 and 56.9, respectively, P < 0.001). The rate of RSV infection appeared to correlate with the monthly number of rain days (r = 0.26, P < 0.01), and inversely with the monthly mean temperature (r = -0.38, P < 0.001). In the tropics, seasonal variations in the incidence of RSV infection are evident, with an annual peak in November, December, and January. This information provides a guide for healthcare provisions and implementation of RSV prevention. © 2002 Wiley-Liss, Inc.||Source Title:||Pediatric Pulmonology||URI:||http://scholarbank.nus.edu.sg/handle/10635/101632||ISSN:||87556863||DOI:||10.1002/ppul.10095|
|Appears in Collections:||Staff Publications|
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