Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.ijpharm.2004.12.025
Title: Pharmacological activity of peroral chitosan-insulin nanoparticles in diabetic rats
Authors: Ma, Z.
Lim, T.M. 
Lim, L.-Y. 
Keywords: Chitosan
Diabetes
Insulin
Nanoparticles
Oral delivery
Issue Date: 11-Apr-2005
Citation: Ma, Z., Lim, T.M., Lim, L.-Y. (2005-04-11). Pharmacological activity of peroral chitosan-insulin nanoparticles in diabetic rats. International Journal of Pharmaceutics 293 (1-2) : 271-280. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ijpharm.2004.12.025
Abstract: The objective of the present study was to evaluate the effects of formulation parameters on the in vivo pharmacological activity of the chitosan-insulin nanoparticles. Chitosan-insulin nanoparticles were prepared by ionotropic gelation at pH 5.3 and 6.1 and denoted as F5.3np and F6.1np, respectively. F5.3np and F6.1np administered orally at insulin doses of 50 U/kg and/or 100 U/kg were effective at lowering the serum glucose level of streptozotocin-induced diabetic rats. The 100 U/kg-dose F5.3np sustained the serum glucose at pre-diabetic levels for at least 11 h. In comparison, F6.1np had a faster onset of action (2 h versus 10 h) but lower efficiency. The effectiveness of peroral F5.3np and F6.1np in lowering the serum glucose level of streptozotocin-induced diabetic rats was ascribed to the local effect of insulin in intestine. Confocal micrographs showed strong interaction between rat intestinal epithelium and chitosan nanoparticles 3 h post-oral administration. © 2005 Elsevier B.V. All rights reserved.
Source Title: International Journal of Pharmaceutics
URI: http://scholarbank.nus.edu.sg/handle/10635/101366
ISSN: 03785173
DOI: 10.1016/j.ijpharm.2004.12.025
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

172
checked on Aug 21, 2019

WEB OF SCIENCETM
Citations

155
checked on Aug 21, 2019

Page view(s)

64
checked on Aug 17, 2019

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.