Please use this identifier to cite or link to this item: https://doi.org/10.1074/jbc.M109.007823
DC FieldValue
dc.titleLoss of Wip1 sensitizes cells to stress- and DNA damage-induced apoptosis
dc.contributor.authorXia, Y.
dc.contributor.authorOngusaha, P.
dc.contributor.authorLee, S.W.
dc.contributor.authorLiou, Y.-C.
dc.date.accessioned2014-10-27T08:32:49Z
dc.date.available2014-10-27T08:32:49Z
dc.date.issued2009-06-26
dc.identifier.citationXia, Y., Ongusaha, P., Lee, S.W., Liou, Y.-C. (2009-06-26). Loss of Wip1 sensitizes cells to stress- and DNA damage-induced apoptosis. Journal of Biological Chemistry 284 (26) : 17428-17437. ScholarBank@NUS Repository. https://doi.org/10.1074/jbc.M109.007823
dc.identifier.issn00219258
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/101035
dc.description.abstractIn response to various environmental stresses, the stress-responsive MAPKs p38 and JNK are activated and phosphorylate ATF2 and c-Jun transcription factors, thereby affecting cell-fate decision. Targeted gene disruption studies have established that JNK-c-Jun signaling plays a vital role in stress-induced apoptosis. The oncogenic phosphatase Wip1 acts as an important regulator in DNA damage pathway by dephosphorylating a spectrum of proteins including p53, p38, Chk1, Chk2, and ATM. In this study we show that Wip1 negatively regulates the activation of MKK4-JNK-c-Jun signaling during stress-induced apoptosis. The loss of Wip1 function sensitizes mouse embryonic fibroblasts to stress-induced apoptosis via the activation of both p38- ATF2 and JNK-c-Jun signaling. Here we reveal that Wip1 has dual roles in alternatively regulating stress- and DNA damageinduced apoptosis through p38/JNK MAPKs and p38/p53-dependent pathways, respectively. Our results point to Wip1 as a general regulator of apoptosis, which further supports its role in tumorigenesis. © 2009 by The American Society for Biochemistry and Molecular Biology, Inc.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1074/jbc.M109.007823
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.description.doi10.1074/jbc.M109.007823
dc.description.sourcetitleJournal of Biological Chemistry
dc.description.volume284
dc.description.issue26
dc.description.page17428-17437
dc.description.codenJBCHA
dc.identifier.isiut000267202500009
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

30
checked on Jul 19, 2019

WEB OF SCIENCETM
Citations

29
checked on Jul 19, 2019

Page view(s)

46
checked on Jul 20, 2019

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.