Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.cell.2008.04.043
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dc.titleIntegration of External Signaling Pathways with the Core Transcriptional Network in Embryonic Stem Cells
dc.contributor.authorChen, X.
dc.contributor.authorXu, H.
dc.contributor.authorYuan, P.
dc.contributor.authorFang, F.
dc.contributor.authorHuss, M.
dc.contributor.authorVega, V.B.
dc.contributor.authorWong, E.
dc.contributor.authorOrlov, Y.L.
dc.contributor.authorZhang, W.
dc.contributor.authorJiang, J.
dc.contributor.authorLoh, Y.-H.
dc.contributor.authorYeo, H.C.
dc.contributor.authorYeo, Z.X.
dc.contributor.authorNarang, V.
dc.contributor.authorGovindarajan, K.R.
dc.contributor.authorLeong, B.
dc.contributor.authorShahab, A.
dc.contributor.authorRuan, Y.
dc.contributor.authorBourque, G.
dc.contributor.authorSung, W.-K.
dc.contributor.authorClarke, N.D.
dc.contributor.authorWei, C.-L.
dc.contributor.authorNg, H.-H.
dc.date.accessioned2014-10-27T08:31:49Z
dc.date.available2014-10-27T08:31:49Z
dc.date.issued2008-06-13
dc.identifier.citationChen, X., Xu, H., Yuan, P., Fang, F., Huss, M., Vega, V.B., Wong, E., Orlov, Y.L., Zhang, W., Jiang, J., Loh, Y.-H., Yeo, H.C., Yeo, Z.X., Narang, V., Govindarajan, K.R., Leong, B., Shahab, A., Ruan, Y., Bourque, G., Sung, W.-K., Clarke, N.D., Wei, C.-L., Ng, H.-H. (2008-06-13). Integration of External Signaling Pathways with the Core Transcriptional Network in Embryonic Stem Cells. Cell 133 (6) : 1106-1117. ScholarBank@NUS Repository. https://doi.org/10.1016/j.cell.2008.04.043
dc.identifier.issn00928674
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/100944
dc.description.abstractTranscription factors (TFs) and their specific interactions with targets are crucial for specifying gene-expression programs. To gain insights into the transcriptional regulatory networks in embryonic stem (ES) cells, we use chromatin immunoprecipitation coupled with ultra-high-throughput DNA sequencing (ChIP-seq) to map the locations of 13 sequence-specific TFs (Nanog, Oct4, STAT3, Smad1, Sox2, Zfx, c-Myc, n-Myc, Klf4, Esrrb, Tcfcp2l1, E2f1, and CTCF) and 2 transcription regulators (p300 and Suz12). These factors are known to play different roles in ES-cell biology as components of the LIF and BMP signaling pathways, self-renewal regulators, and key reprogramming factors. Our study provides insights into the integration of the signaling pathways into the ES-cell-specific transcription circuitries. Intriguingly, we find specific genomic regions extensively targeted by different TFs. Collectively, the comprehensive mapping of TF-binding sites identifies important features of the transcriptional regulatory networks that define ES-cell identity. © 2008 Elsevier Inc. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.cell.2008.04.043
dc.sourceScopus
dc.subjectDNA
dc.subjectPROTEINS
dc.subjectSTEMCELL
dc.typeArticle
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.description.doi10.1016/j.cell.2008.04.043
dc.description.sourcetitleCell
dc.description.volume133
dc.description.issue6
dc.description.page1106-1117
dc.description.codenCELLB
dc.identifier.isiut000256693400024
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