Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.toxicon.2004.03.012
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dc.titleIn vitro neuromuscular activity of 'colubrid' venoms: Clinical and evolutionary implications
dc.contributor.authorLumsden, N.G.
dc.contributor.authorFry, B.G.
dc.contributor.authorManjunatha Kini, R.
dc.contributor.authorHodgson, W.C.
dc.date.accessioned2014-10-27T08:31:20Z
dc.date.available2014-10-27T08:31:20Z
dc.date.issued2004-06
dc.identifier.citationLumsden, N.G., Fry, B.G., Manjunatha Kini, R., Hodgson, W.C. (2004-06). In vitro neuromuscular activity of 'colubrid' venoms: Clinical and evolutionary implications. Toxicon 43 (7) : 819-827. ScholarBank@NUS Repository. https://doi.org/10.1016/j.toxicon.2004.03.012
dc.identifier.issn00410101
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/100902
dc.description.abstractIn this study, venoms from species in the Colubrinae, Homalopsinae, Natricinae, Pseudoxyrhophiinae and Psammophiinae snake families were assayed for activity in the chick biventer cervicis skeletal nerve muscle preparation. Boiga dendrophila, Boiga cynodon, Boiga dendrophila gemincincta, Boiga drapiezii, Boiga irregularis, Boiga nigriceps and Telescopus dhara venoms (10 μg/ml) displayed postsynaptic neuromuscular activity as evidenced by inhibition of indirect (0.1 Hz, 0.2 ms, supramaximal V) twitches. Neostigmine (5 μM) reversed the inhibition caused by B. cynodon venom (10 μg/ml) while the inhibitory effects of Psammophis mossambicus venom (10 μg/ml) spontaneously reversed, indicating a reversible mode of action for both venoms. Trimorphodon biscutatus (10 μg/ml) displayed irreversible presynaptic neurotoxic activity. Detectable levels of phospholipase A 2 activity were found only in T. biscutatus, T. dhara and P. mossambicus venoms. The results demonstrate a hitherto unsuspected diversity of pharmacological actions in all lineages which may have implications ranging from clinical management of envenomings to venom evolution. © 2004 Elsevier Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.toxicon.2004.03.012
dc.sourceScopus
dc.subjectChick biventer cervicis
dc.subjectColubroidea
dc.subjectNeostigmine
dc.subjectNeuromuscular
dc.subjectVenom
dc.typeArticle
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.description.doi10.1016/j.toxicon.2004.03.012
dc.description.sourcetitleToxicon
dc.description.volume43
dc.description.issue7
dc.description.page819-827
dc.description.codenTOXIA
dc.identifier.isiut000221821700009
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