Please use this identifier to cite or link to this item: https://doi.org/10.1007/s004360000366
Title: Immune-mediated parasite clearance in mice infected with Plasmodium berghei following treatment with manzamine A
Authors: Ang, K.
Holmes, M. 
Kara, U. 
Issue Date: 2001
Citation: Ang, K., Holmes, M., Kara, U. (2001). Immune-mediated parasite clearance in mice infected with Plasmodium berghei following treatment with manzamine A. Parasitology Research 87 (9) : 715-721. ScholarBank@NUS Repository. https://doi.org/10.1007/s004360000366
Abstract: Manzamine A, a sponge-derived alkaloid, was recently shown to possess in vivo antimalarial activity against the blood stages of the rodent malaria parasite Plasmodium berghei. A single intraperitoneal dose of 100 μmol/kg of manzamine A suppressed parasite growth but was followed by parasite recrudescence. Forty percent of mice with recrudescing parasites were able to recover and clear the fulminating parasitaemia. Examination of sera from these mice revealed that infected mice treated with manzamine A had a suppressed IFN-γ production but an increase in their IL-10 and IgG production. The prolonged survival of infected mice treated with manzamine A and the eventual clearance of recrudescing parasites in some of these mice involve a down-regulation of Th1 responses and a switch to antibody dependent-Th2 responses.
Source Title: Parasitology Research
URI: http://scholarbank.nus.edu.sg/handle/10635/100887
ISSN: 09320113
DOI: 10.1007/s004360000366
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