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Please use this identifier to cite or link to this item: https://doi.org/10.1007/s00216-007-1629-9
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dc.titleEx-vivo NMR of unprocessed tissue in water: A simplified procedure for studying intracranial neoplasms
dc.contributor.authorXu, M.
dc.contributor.authorYe, J.
dc.contributor.authorYang, D.
dc.contributor.authorXu, X.
dc.contributor.authorYeo, T.T.
dc.contributor.authorNg, W.H.
dc.contributor.authorLim, C.C.
dc.date.accessioned2014-10-27T08:28:17Z
dc.date.available2014-10-27T08:28:17Z
dc.date.issued2007-12
dc.identifier.citationXu, M., Ye, J., Yang, D., Xu, X., Yeo, T.T., Ng, W.H., Lim, C.C. (2007-12). Ex-vivo NMR of unprocessed tissue in water: A simplified procedure for studying intracranial neoplasms. Analytical and Bioanalytical Chemistry 389 (7-8) : 2153-2159. ScholarBank@NUS Repository. https://doi.org/10.1007/s00216-007-1629-9
dc.identifier.issn16182642
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/100659
dc.description.abstractEx-vivo and in-vitro nuclear magnetic resonance (NMR) spectroscopy techniques have been used for studying chemical metabolites in surgically resected specimens of human neoplasms, and may provide complementary information to in-vivo whole-body magnetic-resonance spectroscopy (MRS). We describe an ex-vivo NMR in water method for measurement of water-soluble metabolites in unprocessed normal rat brain tissue and human intracranial neoplasms. The NMR spectra obtained using the method described here were comparable to those obtained using high-resolution magic-angle spinning (HRMAS) NMR methods, with good correlation in metabolite concentrations relative to creatine (r 2 = 0.7635). Improved spectral resolution and baseline were noted compared to HRMAS, but macromolecule resonances were not detected. Ex-vivo NMR of unprocessed tissue in water is rapid and technically simple to perform, and has the potential to be used for direct assessment of intracranial neoplasms. © 2007 Springer-Verlag.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1007/s00216-007-1629-9
dc.sourceScopus
dc.subjectBrain neoplasm
dc.subjectCholine
dc.subjectHigh-resolution magic-angle spinning
dc.subjectNuclear magnetic resonance
dc.subjectRat brain
dc.typeArticle
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.description.doi10.1007/s00216-007-1629-9
dc.description.sourcetitleAnalytical and Bioanalytical Chemistry
dc.description.volume389
dc.description.issue7-8
dc.description.page2153-2159
dc.description.codenABCNB
dc.identifier.isiut000251320100012
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