Please use this identifier to cite or link to this item:
|Title:||Differential interleukin-10 expression in interferon regulatory factor-1 deficient mice during Plasmodium berghei blood-stage infection||Authors:||Tan, R.S.-P.
|Keywords:||Interferon regulatory factor-1
|Issue Date:||2000||Citation:||Tan, R.S.-P., Kara, A.U., Feng, C., Asano, Y., Sinniah, R. (2000). Differential interleukin-10 expression in interferon regulatory factor-1 deficient mice during Plasmodium berghei blood-stage infection. Parasite Immunology 22 (9) : 425-435. ScholarBank@NUS Repository. https://doi.org/10.1046/j.1365-3024.2000.00312.x||Abstract:||Mice deficient of functional interferon regulatory factor-1 (IRF-1-/-) by targeted gene disruption infected with a lethal murine malaria strain, Plasmodium berghei ANKA survived longer than its wild-type littermates despite the inability to induce appreciable amounts of interferon-gamma (IFN-γ) and nitric oxide. In addition, infected IRF-1-/- mice displayed less organ injury with reduced necrosis and inflammation. Both wild-type and IRF-1-/- mice treated with exogenous interleukin-12 (IL-12) suffered extensive organ damage with corresponding up regulation of IFN-γ, suggesting the pathogenic potential of IL-12 and IFN-γ. IL-10 is a cytokine produced by CD4+ T lymphocytes belonging to the Th2 subset. Expression of IL-10 in the wild-type mice correlated with the severity of the infection, with higher mRNA expression towards the later stage of infection. In contrast to the wild-type mice, IL-10 levels in the IRF-1-/- mice were induced early in the infection and decreased gradually as the infection progressed. Both untreated and IL-12 treated wild-type mice appeared to follow a Th1-like immune response early in the infection and Th2-like immune response later in the infection. However, the IRF-1-/- mice were able to launch an altered immune response with a Th2-like immune response early in the infection. These findings suggest that IL-10 expression in the IRF-1-/- mice during the early stage of P. berghei ANKA infection could play an important role in suppressing pathogenic effects of a cell mediated immune response and promoting protective immunity against the parasite.||Source Title:||Parasite Immunology||URI:||http://scholarbank.nus.edu.sg/handle/10635/100460||ISSN:||01419838||DOI:||10.1046/j.1365-3024.2000.00312.x|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Apr 5, 2021
WEB OF SCIENCETM
checked on Apr 5, 2021
checked on Mar 28, 2021
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.