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Title: Cytokine-mediated antimicrobial immune response of catfish, Clarias gariepinus, as a defence against Aeromonas hydrophila
Authors: Yin, Z.
Lam, T.J. 
Sin, Y.M. 
Keywords: Aeromonas hydrophila
Bactericidal activity
Clarias gariepinus
Issue Date: Feb-1997
Citation: Yin, Z.,Lam, T.J.,Sin, Y.M. (1997-02). Cytokine-mediated antimicrobial immune response of catfish, Clarias gariepinus, as a defence against Aeromonas hydrophila. Fish and Shellfish Immunology 7 (2) : 93-104. ScholarBank@NUS Repository.
Abstract: The proliferative response of head kidney (HK) leucocytes from catfish (Clarias gariepinus) immunised against Aeromonas hydrophila strain PPD 134/91 was significantly increased compared with that of naive HK leucocytes using whole bacterial cells as the in vitro stimulant. A correlation between the proliferation of immune HK leucocytes and the production of macrophage-activating factor (MAF) was also observed. The production of reactive oxygen and nitrogen intermediates from the resident phagocytes of control fish was enhanced after incubating with the MAF-containing supernatants for 48 h. Both cytokine-containing supernatants and the incubated phagocytes of the immune fish also exhibited a significant increase of bactericidal activity. The study also showed that nitric oxide (NO) production and microbicidal activity of the antigen-activated phagocytes were partially blocked with NG-monomethyl-L-arginine (NG-MMLA), suggesting that NO might be an important antimicrobial effector in fish phagocytes as in mammals. © 1997 Academic Press Limited.
Source Title: Fish and Shellfish Immunology
ISSN: 10504648
Appears in Collections:Staff Publications

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