Please use this identifier to cite or link to this item: https://doi.org/10.2174/092986609788167842
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dc.titleChitinases: Biomarkers for human diseases
dc.contributor.authorGuan, S.-P.
dc.contributor.authorMok, Y.-K.
dc.contributor.authorKoo, K.-N.
dc.contributor.authorChu, K.-L.
dc.contributor.authorWong, W.S.F.
dc.date.accessioned2014-10-27T08:23:50Z
dc.date.available2014-10-27T08:23:50Z
dc.date.issued2009-05
dc.identifier.citationGuan, S.-P., Mok, Y.-K., Koo, K.-N., Chu, K.-L., Wong, W.S.F. (2009-05). Chitinases: Biomarkers for human diseases. Protein and Peptide Letters 16 (5) : 490-498. ScholarBank@NUS Repository. https://doi.org/10.2174/092986609788167842
dc.identifier.issn09298665
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/100261
dc.description.abstractHuman chitinases (EC.3.2.1.14) are classified into family 18 of glycosyl hydrolase (GH18) superfamily based on their amino acid sequence similarities. Active chitinase hydrolyzes chitin, a p-1,4-linked N-acetyl-D-glucosamine oligosaccharide. Chitin is a major structural component of the insect exoskeletons and fungal cell walls, but is not found in vertebrates. In human, eight GH18 chitinases have been identified including active chitotriosidase and acidic mammalian chitinase. Most of the human chitinases lack chitinolytic activity due to mutation of an essential glutamic acid residue at the catalytic domain, and they are termed chitolectin. This review highlights some characteristics of human chitinases, compares structural differences among some human GH18 members, and discusses their cellular regulation and function. Finally, we summarize current views on the role of human chitinases in a variety of human diseases. © 2009 Bentham Science Publishers Ltd.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.2174/092986609788167842
dc.sourceScopus
dc.subjectAcidic mammalian chitinase
dc.subjectChitotriosidase
dc.subjectOviductin
dc.subjectYKL-39
dc.subjectYKL-40
dc.typeArticle
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.description.doi10.2174/092986609788167842
dc.description.sourcetitleProtein and Peptide Letters
dc.description.volume16
dc.description.issue5
dc.description.page490-498
dc.description.codenPPELE
dc.identifier.isiut000265799400007
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