Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/100210
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dc.titleCancer Chemopreventive Activity of Rotenoids from Derris trifoliata
dc.contributor.authorIto, C.
dc.contributor.authorItoigawa, M.
dc.contributor.authorKojima, N.
dc.contributor.authorTan, H.T.-W.
dc.contributor.authorTakayasu, J.
dc.contributor.authorTokuda, H.
dc.contributor.authorNishino, H.
dc.contributor.authorFurukawa, H.
dc.date.accessioned2014-10-27T08:23:16Z
dc.date.available2014-10-27T08:23:16Z
dc.date.issued2004-01
dc.identifier.citationIto, C.,Itoigawa, M.,Kojima, N.,Tan, H.T.-W.,Takayasu, J.,Tokuda, H.,Nishino, H.,Furukawa, H. (2004-01). Cancer Chemopreventive Activity of Rotenoids from Derris trifoliata. Planta Medica 70 (1) : 8-11. ScholarBank@NUS Repository.
dc.identifier.issn00320943
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/100210
dc.description.abstractA study of the chemical constituents of the stems of Derris trifoliata Lour. (Leguminosae) led to the isolation and identification of one new rotenoid, 6aα,12aα-12a-hydroxyelliptone (3), together with five other known rotenoids. In a search for novel cancer chemopreventive agents (anti-tumor promoters), we carried out a primary screening of five of the rotenoids isolated from the plant for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol 13-acetate (TPA) in Raji cells. The inhibitory activity of 3 was found to be equivalent to that of β-carotene without any cytotoxicity. Deguelin (4) and α-toxicarol (5) exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. This investigation indicated that rotenoids might be valuable anti-tumor promoters.
dc.sourceScopus
dc.subjectAnti-tumor promoters
dc.subjectCancer chemopreventive agents
dc.subjectDerris trifoliata
dc.subjectLeguminosae
dc.subjectRotenoid
dc.typeArticle
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.description.sourcetitlePlanta Medica
dc.description.volume70
dc.description.issue1
dc.description.page8-11
dc.description.codenPLMEA
dc.identifier.isiutNOT_IN_WOS
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