The giant mudskipper Periophthalmodon schlosseri facilitates active NH 4 + excretion by increasing acid excretion and decreasing NH3 permeability in the skin
Ip, Y.K. Randall, D.J. Kok, T.K.T. Barzaghi, C. Wright, P.A. Ballantyne, J.S. Wilson, J.M. Chew, S.F.
Randall, D.J.
Kok, T.K.T.
Barzaghi, C.
Wright, P.A.
Ballantyne, J.S.
Wilson, J.M.
Chew, S.F.
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Alternative Title
Abstract
Periophthalmodon schlosseri is an amphibious and obligatory air-breathing teleost, which is extremely tolerant to environmental ammonia. It actively excretes NH4 + in ammonia loading conditions. For such a mechanism to operate efficaciously the fish must be able to prevent back flux of NH3. P. schlosseri could lower the pH of 50 volumes (w/v) of 50% seawater in an artificial burrow from pH 8.2 to pH 7.4 in 1 day, and established an ambient ammonia concentration of 10 mmol l-1 in 8 days. It could alter the rate of titratable acid efflux in response to ambient pH. The rate of net acid efflux (H+ excretion) in P. schlosseri was pH-dependent, increasing in the order pH 6.0
Keywords
Ammonia, Cholesterol, Excretion, Fatty acid, Gill, H +-ATPase, Lipid, Membrane, Membrane fluidity, Mudskipper, Periophthalmodon schlosseri, Permeability, Phospholipid, Proton pump, Skin
Source Title
Journal of Experimental Biology
Publisher
Series/Report No.
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Date
2004-02
DOI
10.1242/jeb.00788
Type
Article