Precise Two-Photon Photodynamic Therapy using an Efficient Photosensitizer with Aggregation-Induced Emission Characteristics
Gu, Bobo Wu, Wenbo Xu, Gaixia FENG GUANGXUE Yin, Feng Chong, Peter Han Joo Qu, Junle Yong, Ken-Tye LIU BIN
Gu, Bobo
Wu, Wenbo
Xu, Gaixia
Yin, Feng
Chong, Peter Han Joo
Qu, Junle
Yong, Ken-Tye
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Abstract
Two-photon photodynamic therapy (PDT) is able to offer precise 3D manipulation of treatment volumes, providing a target level that is unattainable with current therapeutic techniques. The advancement of this technique is greatly hampered by the availability of photosensitizers with large two-photon absorption (TPA) cross section, high reactive-oxygen-species (ROS) generation efficiency, and bright two-photon fluorescence. Here, an effective photosensitizer with aggregation-induced emission (AIE) characteristics is synthesized, characterized, and encapsulated into an amphiphilic block copolymer to form organic dots for two-photon PDT applications. The AIE dots possess large TPA cross section, high ROS generation efficiency, and excellent photostability and biocompatibility, which overcomes the limitations of many conventional two-photon photosensitizers. Outstanding therapeutic performance of the AIE dots in two-photon PDT is demonstrated using in vitro cancer cell ablation and in vivo brain-blood-vessel closure as examples. This shows therapy precision up to 5 µm under two-photon excitation.
Keywords
Science & Technology, Physical Sciences, Technology, Chemistry, Multidisciplinary, Chemistry, Physical, Nanoscience & Nanotechnology, Materials Science, Multidisciplinary, Physics, Applied, Physics, Condensed Matter, Chemistry, Science & Technology - Other Topics, Materials Science, Physics, aggregation-induced emission, brain-blood-vessel closure, cancer cells, photodynamic therapy, two-photon excitation, FLUORESCENT ORGANIC DOTS, IN-VITRO, CELL, NANOPARTICLES, ABSORPTION, CANCER, EXCITATION, DESIGN
Source Title
Advanced Materials
Publisher
Wiley-VCH Verlag
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Date
2017-07-26
DOI
10.1002/adma.201701076
Type
Article