Sparse evidence of MERS-CoV infection among animal workers living in Southern Saudi Arabia during 2012
Memish, Z.A Alsahly, A Masri, M.al Heil, G.L Anderson, B.D Peiris, M Khan, S.U Gray, G.C
Memish, Z.A
Alsahly, A
Masri, M.al
Heil, G.L
Anderson, B.D
Peiris, M
Khan, S.U
Citations
Altmetric:
Alternative Title
Abstract
Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging viral pathogen that primarily causes respiratory illness. We conducted a seroprevalence study of banked human serum samples collected in 2012 from Southern Saudi Arabia. Sera from 300 animal workers (17% with daily camel exposure) and 50 non-animal-exposed controls were examined for serological evidence of MERS-CoV infection by a pseudoparticle MERS-CoV spike protein neutralization assay. None of the sera reproducibly neutralized the MERS-CoV-pseudotyped lentiviral vector. These data suggest that serological evidence of zoonotic transmission of MERS-CoV was not common among animal workers in Southern Saudi Arabia during July 2012. © 2014 The Authors.
Keywords
lentivirus vector, virus protein, virus antibody, adolescent, adult, aged, antibody titer, Article, blood sampling, controlled study, Coronavirus infection, female, human, major clinical study, male, Middle East respiratory syndrome coronavirus, Middle East respiratory syndrome coronavirus infection, occupational exposure, priority journal, Saudi Arabia, serology, seroprevalence, serum, viral respiratory tract infection, virus neutralization, virus particle, virus transmission, worker, animal, blood, camel, Coronavirus Infections, immunology, middle aged, Middle East respiratory syndrome coronavirus, serodiagnosis, transmission, very elderly, young adult, Adolescent, Adult, Aged, Aged, 80 and over, Animals, Antibodies, Viral, Camels, Coronavirus Infections, Female, Humans, Male, Middle Aged, Middle East Respiratory Syndrome Coronavirus, Neutralization Tests, Saudi Arabia, Seroepidemiologic Studies, Young Adult
Source Title
Influenza and other Respiratory Viruses
Publisher
Series/Report No.
Collections
Rights
Attribution 4.0 International
Date
2015
DOI
10.1111/irv.12287
Type
Article