3D-CT implanted interstitial brachytherapy for T2b nasopharyngeal carcinoma
Ren, Y.-F Gao, Y.-H Cao, X.-P Ye, W.-J Teh, B.S
Ren, Y.-F
Gao, Y.-H
Cao, X.-P
Ye, W.-J
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Alternative Title
Abstract
Background: To compare the results of external beam radiotherapy in combination with 3D- computed tomography (CT)-implanted interstitial high dose rate brachytherapy (ERT/3D-HDR-BT) versus conventional external beam radiotherapy (ERT) for the treatment of stage T2b nasopharyngeal carcinoma (NPC).Methods: Forty NPC patients diagnosed with stage T2b NPC were treated with ERT/3D-HDR-BT under local anesthesia. These patients received a mean dose of 60 Gy, followed by 12-20 Gy administered by 3D-HDR-BT. Another 101 patients diagnosed with non-metastatic T2b NPC received a mean dose of 68 Gy by ERT alone during the same period.Results: Patients treated with ERT/3D-HDR-BT versus ERT alone exhibited an improvement in their 5-y local failure-free survival rate (97.5% vs. 80.2%, P = 0.012) and disease-free survival rate (92.5% vs. 73.3%, P = 0.014). Using multivariate analysis, administration of 3D-HDR-BT was found to be favorable for local control (P = 0.046) and was statistically significant for disease-free survival (P = 0.021). The incidence rate of acute and chronic complications between the two groups was also compared.Conclusions: It is possible that the treatment modality enhances local control due to improved conformal dose distributions and the escalated radiation dose applied. © 2010 Ren et al; licensee BioMed Central Ltd.
Keywords
adult, aged, article, bleeding, brachytherapy, clinical article, computer assisted tomography, controlled study, cranial nerve paralysis, disease course, disease free survival, disease severity, endocrine disease, external beam radiotherapy, female, fibrosis, hearing impairment, human, human tissue, hypophysis disease, incidence, local anesthesia, male, mucosa inflammation, multivariate analysis, nasopharynx carcinoma, necrosis, radiation dose, radiation dose distribution, survival rate, three dimensional imaging, treatment duration, xerostomia, brachytherapy, cancer staging, carcinoma, computer assisted radiotherapy, evaluation, follow up, methodology, middle aged, mortality, nasopharynx tumor, pathology, retrospective study, Adult, Brachytherapy, Carcinoma, Female, Follow-Up Studies, Humans, Imaging, Three-Dimensional, Male, Middle Aged, Nasopharyngeal Neoplasms, Neoplasm Staging, Radiotherapy Dosage, Radiotherapy Planning, Computer-Assisted, Retrospective Studies, Survival Rate, Tomography, X-Ray Computed
Source Title
Radiation Oncology
Publisher
BMC
Series/Report No.
Collections
Rights
Attribution 4.0 International
Date
2010
DOI
10.1186/1748-717X-5-113
Type
Article