Wong Poo Sing
Email Address
surwps@nus.edu.sg
Organizational Units
YONG LOO LIN SCH OF MEDICINE
faculty
SURGERY
dept
20 results
Publication Search Results
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Publication An unusual cause for palpitations(2005-03) Asmat, A.; Wong, P.-S.; SURGERYPublication Small cell neuroendocrine carcinoma presenting as a pulmonary artery mass(2007) Teo, T.K.B.; Venkatesh, S.K.; Tan, L.K.A.; Wong, P.S.; DIAGNOSTIC RADIOLOGY; SURGERY; DUKE-NUS GRADUATE MEDICAL SCHOOL S'POREPublication Combined Open and Endovascular Repair of Acute Type A Aortic Dissection(2007) Sorokin, V.A.; Chong, C.F.; Lee, C.N.; Wong, P.S.; Tan, L.; Robless, P.A.; DIAGNOSTIC RADIOLOGY; SURGERYA 62-year-old man with an acute Stanford type A dissection underwent successful emergent replacement of the ascending aorta. The patient was readmitted with a left pleural effusion and complex dissection in the arch and descending thoracic aorta. A hybrid surgical procedure was performed involving complete arch transposition, followed by arch and descending aortic stenting, with a good result. The surgical management and techniques are reviewed. © 2007 The Society of Thoracic Surgeons.Publication An alternative approach to determining therapeutic choices in advanced non-small cell lung carcinoma (NSCLC): Maximizing the diagnostic procedure and the use of low-volume lung biopsies(2007) Lim, E.H.; Zhang, S.-L.; Yu, K.; Tan, P.; Nga, M.-E.; Ahmed, D.A.; Agasthian, T.; Wong, P.-S.; Chua, G.-C.; Wong, D.; Tan, L.; Seto, K.-Y.; Yap, W.-S.; Ng, A.; Low, S.-P.; Khoo, K.-L.; Chang, A.; MEDICINE; PHYSIOLOGY; SURGERY; PATHOLOGYPublication Comparison of clinical with pathological nodal staging from systematic mediastinal lymph node dissection in early resectable non-small cell lung cancer(2007) Chong, C.F.; Lee, C.N.; Wong, P.S.; Khoo, K.L.; Lim, T.K.; Lim, H.L.; Chang, A.Y.; MEDICINE; SURGERYPublication Feasibility of Using Low-Volume Tissue Samples for Gene Expression Profiling of Advanced Non-Small Cell Lung Cancers(2003-12-01) Lim, E.H.; Aggarwal, A.; Agasthian, T.; Wong, P.-S.; Tan, C.; Sim, E.; Tan, L.; Goh Poh Sun; Wang, S.-C.; Khoo, K.-L.; Mukherjee, A.; Khoo, S.-M.; Chua, G.; Nilsson, B.; Lee, K.-H.; Tan, P.; MEDICINE; SURGERY; PATHOLOGYPurpose: The majority of patients with non-small cell lung cancer (NSCLC) present at an advanced clinical stage, when surgery is not a recommended therapeutic option. In such cases, tissues for molecular research are usually limited to the low-volume samples obtained at the time of diagnosis, usually via fine-needle aspiration (FNA). We tested the feasibility of performing gene expression profiling of advanced NSCLCs using amplified RNA from lung FNAs. Experimental Design and Results: A total of 46 FNAs was tested, of which 18 yielded RNA of sufficient quality for microarray analysis. Expression profiles of these 18 samples were compared with profiles of 17 pairs of tumor and normal lung tissues that had been surgically obtained. Using a variety of unsupervised and supervised analytical approaches, we found that the FNA profiles were highly distinct from the normal samples and similar to the tumor profiles. Conclusions: We conclude that when RNA amplification is successful, gene expression profiles from NSCLC FNAs can determine malignancy and suggest that with additional refinement and standardization of sample collection and RNA amplification protocols, it will be possible to conduct additional and more detailed molecular analysis of advanced NSCLC using lung FNAs.Publication Surgical coronary revascularization in severe left ventricular dysfunction(2007) Chong, C.F.; Fazuludeen, A.A.; Tan, C.; Da, Costa M.; Wong, P.S.; Lee, C.N.; SURGERYPublication Contractile and vasorelaxant effects of hydrogen sulfide and its biosynthesis in the human internal mammary artery(2008) Webb, G.D.; Oh, V.M.S.; Soh, B.Y.; Taylor, E.A.; Lay, H.L.; Yoke, P.C.; Ali, M.Y.; Bhatia, M.; Moore, P.K.; El, Oakley R.; Chuen, N.L.; Poo, S.W.; Caleb, M.G.; Salto-Tellez, M.; Chan, E.S.Y.; PHARMACOLOGY; MEDICINE; SURGERY; PATHOLOGYPublication Expression of neuronal nitric oxide synthase in the internal thoracic artery and saphenous vein(2006) Webb, G.D.; Lim, L.H.; Moore, P.K.; Oh, V.M.S.; El, Oakley R.; Lee, C.N.; Wong, P.S.; Aye, W.M.M.; Chan, E.S.Y.; PHARMACOLOGY; MEDICINE; SURGERYObjectives: Endothelial nitric oxide synthase (type III) generates nitric oxide, which dilates blood vessels. Recently, it was discovered that arterial smooth muscle cells express neuronal nitric oxide synthase (type I). The purpose of this study was to determine the relative amounts of neuronal nitric oxide synthase in the human internal thoracic artery and saphenous vein. Methods: Remainder segments of internal thoracic arteries and saphenous veins were obtained from 45 patients during coronary artery bypass grafting. Western blotting used specific antibodies against the 3 isoforms of human nitric oxide synthase and β-actin (for normalization) to measure the relative amounts of the 3 isoforms of nitric oxide synthase proteins in vessel specimens. Immunohistochemistry was used to localize the 3 proteins in specific cells. Results: Western blotting detected all 3 isoforms of nitric oxide synthase in the human internal thoracic artery. The band density (normalized to β-actin) of neuronal nitric oxide synthase was not significantly different from the band density of endothelial nitric oxide synthase. The amounts of neuronal nitric oxide synthase in arteries and veins were equal. Immunohistochemistry showed that the highest expression of endothelial nitric oxide synthase was in endothelial cells, but some expression was also seen in smooth muscle cells. Most of the neuronal nitric oxide synthase was in smooth muscle cells. The location and relative amounts of inducible nitric oxide synthase were variable. Conclusions: Neuronal nitric oxide synthase is expressed in the vascular smooth muscle of patients undergoing bypass, and the amount in the internal thoracic artery is the same as in the saphenous vein. © 2006 The American Association for Thoracic Surgery.Publication False aneurysm in pulmonary sequestration(2004) Wong, P.-S.; Ahmed, A.D.B.; Lee, C.-N.; SURGERY