Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/97387
Title: Nuclear microscopy study of neurofibrillary tangles in Alzheimer's disease
Authors: Makjanić, J. 
McDonald, B.
Watt, F. 
Issue Date: Jul-1997
Citation: Makjanić, J.,McDonald, B.,Watt, F. (1997-07). Nuclear microscopy study of neurofibrillary tangles in Alzheimer's disease. Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms 130 (1-4) : 439-443. ScholarBank@NUS Repository.
Abstract: The NUS nuclear microscope has been utilized to determine aluminium concentrations in normal and neurofibrillary-tangle-bearing neurons in brain tissue sections from Alzheimer's patients. It was demonstrated that both neurons and neurofibrillary tangles can be identified by STIM in situ in thin tissue. High aluminium levels of up to 500 parts per million were found in tissue fixed with osmium tetroxide, with higher concentrations present in neurons than in surrounding tissue. Preliminary results on untreated freeze dried sections however have yielded an absence of aluminium down to the minimum detection limits of 20 ppm, implying that aluminium is an artifact introduced during sample preparation.
Source Title: Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms
URI: http://scholarbank.nus.edu.sg/handle/10635/97387
ISSN: 0168583X
Appears in Collections:Staff Publications

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