Effect of nanochannel geometry on DNA structure in the presence of macromolecular crowding agent

Please use this identifier to cite or link to this item: https://doi.org/10.1021/nl203114f

Title:	Effect of nanochannel geometry on DNA structure in the presence of macromolecular crowding agent
Authors:	Jones, J.J. Van Der Maarel, J.R.C. Doyle, P.S.
Issue Date:	9-Nov-2011
Citation:	Jones, J.J., Van Der Maarel, J.R.C., Doyle, P.S. (2011-11-09). Effect of nanochannel geometry on DNA structure in the presence of macromolecular crowding agent. Nano Letters 11 (11) : 5047-5053. ScholarBank@NUS Repository. https://doi.org/10.1021/nl203114f
Abstract:	We experimentally and numerically study the effects of macromolecular crowding agents on DNA structure when confined to a nanochannel. Curiously, DNA response to crowding is significantly different between bulk phase, nanoslit confinement, and nanotube confinement. Coarse grained Brownian dynamics simulations reproduce trends seen in the experiments and allow us to develop a deeper understanding of the key physics at play in these systems. It is proposed that the occupancy of free volume next to the channel wall by crowders causes an effective reduction in confining dimensions of the channel that initially swells DNA in nanoconfinement. © 2011 American Chemical Society.
Source Title:	Nano Letters
URI:	http://scholarbank.nus.edu.sg/handle/10635/96325
ISSN:	15306984
DOI:	10.1021/nl203114f
Appears in Collections:	Staff Publications

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