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https://scholarbank.nus.edu.sg/handle/10635/95567
| Title: | MicroRNAs: Biogenesis, function and applications | Authors: | Chua, J.H. Armugam, A. Jeyaseelan, K. |
Keywords: | Antagomir Biomarker Gene silencing MiRNA SiRNA Therapeutic |
Issue Date: | 2009 | Citation: | Chua, J.H.,Armugam, A.,Jeyaseelan, K. (2009). MicroRNAs: Biogenesis, function and applications. Current Opinion in Molecular Therapeutics 11 (2) : 189-199. ScholarBank@NUS Repository. | Abstract: | MicroRNAs (miRNAs) belong to the group of non-coding, small RNAs (19 to 21 nucleotide-long oligonucleotides) that are endogenously produced from their own genes. miRNAs interfere with or affect the transcription or translation of other genes, resulting in gene silencing or activation by a process known as RNAi or RNA activation, respectively. The discovery of miRNAs and related small RNAs within the last 10 years has opened up a new field in biology, called RNomics, which investigates differences in RNA populations and offers great potential in correcting the regulation of abnormally expressed and disease-causing genes, as well as in the development of novel therapeutic agents. This review focuses on the developments in miRNAs and their potential therapeutic applications. © Thomson Reuters (Scientific) Ltd. | Source Title: | Current Opinion in Molecular Therapeutics | URI: | http://scholarbank.nus.edu.sg/handle/10635/95567 | ISSN: | 14648431 |
| Appears in Collections: | Staff Publications |
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