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https://doi.org/10.1016/j.tetlet.2004.10.146
| Title: | Synthetic studies towards anti-SARS agents: Application of an indium-mediated allylation of α-aminoaldehydes as the key step towards an intermediate | Authors: | Chng, S.-S. Hoang, T.-G. Wayne Lee, W.-W. Tham, M.-P. Ling, H.Y. Loh, T.-P. |
Keywords: | AG7088 Anti-SARS agents Diastereoselective Indium-mediated allylation |
Issue Date: | 20-Dec-2004 | Citation: | Chng, S.-S., Hoang, T.-G., Wayne Lee, W.-W., Tham, M.-P., Ling, H.Y., Loh, T.-P. (2004-12-20). Synthetic studies towards anti-SARS agents: Application of an indium-mediated allylation of α-aminoaldehydes as the key step towards an intermediate. Tetrahedron Letters 45 (52) : 9501-9504. ScholarBank@NUS Repository. https://doi.org/10.1016/j.tetlet.2004.10.146 | Abstract: | AG7088 was identified as a good starting point for modification, leading to an efficient and bio-available inhibitor for the SARS coronavirus main proteinase (SARS-CoV M pro). Synthesis of intermediate 1 and analogues proceeded via a highly diastereoselective indium-mediated allylation of α-aminoaldehydes. © 2004 Elsevier Ltd. All rights reserved. | Source Title: | Tetrahedron Letters | URI: | http://scholarbank.nus.edu.sg/handle/10635/95185 | ISSN: | 00404039 | DOI: | 10.1016/j.tetlet.2004.10.146 |
| Appears in Collections: | Staff Publications |
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