Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.ica.2009.12.047
Title: Synthesis, crystal structures, DNA-binding properties, cytotoxic and antioxidation activities of several new ternary copper(II) complexes of N,N′-(p-xylylene)di-alanine acid and 1,10-phenanthroline
Authors: Jia, L.
Jiang, P.
Xu, J.
Hao, Z.-y.
Xu, X.-m.
Chen, L.-h.
Wu, J.-c.
Tang, N.
Wang, Q.
Vittal, J.J. 
Keywords: Cytotoxicity
DNA-binding properties
Phenanthroline base
Reduce Schiff base
Ternary copper(II) complexes
X-ray crystallography
Issue Date: 22-Mar-2010
Citation: Jia, L., Jiang, P., Xu, J., Hao, Z.-y., Xu, X.-m., Chen, L.-h., Wu, J.-c., Tang, N., Wang, Q., Vittal, J.J. (2010-03-22). Synthesis, crystal structures, DNA-binding properties, cytotoxic and antioxidation activities of several new ternary copper(II) complexes of N,N′-(p-xylylene)di-alanine acid and 1,10-phenanthroline. Inorganica Chimica Acta 363 (5) : 855-865. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ica.2009.12.047
Abstract: Three novel ternary copper(II) complexes, [Cu2(phen)2(l-PDIAla)(H2O)2](ClO4)2·2.5H2O (1), [Cu4(phen)6(d,l-PDIAla)(H2O)2](ClO4)6·3H2O (2) and [Cu2(phen)2(d,l-PDIAla)(H2O)](ClO4)2·0.5H2O (3) (phen = 1,10-phenanthroline, H2PDIAla = N,N'-(p-xylylene)di-alanine acid) have been synthesized and structurally characterized by single-crystal X-ray crystallography and other structural analysis. Spectrometric titrations, ethidium bromide displacement experiments, CD (circular dichroism) spectral analysis and viscosity measurements indicate that the three compounds, especially the complex 3, strongly bind to calf-thymus DNA (CT-DNA). The intrinsic binding constants of the ternary copper(II) complexes with CT-DNA are 0.89 × 105, 1.14 × 105 and 1.72 × 105 M-1, for 1, 2 and 3, respectively. Comparative cytotoxic activities of the copper(II) complexes are also determined by acid phosphatase assay. The results show that the ternary copper(II) complexes have significant cytotoxic activity against the HeLa (Cervical cancer), HepG2 (hepatocarcinoma), HL-60 cells (myeloid leukemia), A-549 cells (pulmonary carcinoma) and L02 (liver cells). Investigations of antioxidation properties show that all the copper(II) complexes have strong scavenging effects for hydroxyl radicals and superoxide radicals. © 2009 Elsevier B.V. All rights reserved.
Source Title: Inorganica Chimica Acta
URI: http://scholarbank.nus.edu.sg/handle/10635/95159
ISSN: 00201693
DOI: 10.1016/j.ica.2009.12.047
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