Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.chroma.2010.04.066
Title: Simultaneous extraction of acidic and basic drugs at neutral sample pH: A novel electro-mediated microextraction approach
Authors: Basheer, C.
Lee, J.
Pedersen-Bjergaard, S.
Rasmussen, K.E.
Lee, H.K. 
Keywords: Electromembrane extraction
Gas chromatography-mass spectrometry
Pharmaceuticals
Wastewater analysis
Issue Date: 22-Oct-2010
Source: Basheer, C., Lee, J., Pedersen-Bjergaard, S., Rasmussen, K.E., Lee, H.K. (2010-10-22). Simultaneous extraction of acidic and basic drugs at neutral sample pH: A novel electro-mediated microextraction approach. Journal of Chromatography A 1217 (43) : 6661-6667. ScholarBank@NUS Repository. https://doi.org/10.1016/j.chroma.2010.04.066
Abstract: The simultaneous extraction of acidic and basic analytes from a particular sample is a challenging task. In this work, electromembrane extraction (EME) of acidic non-steroidal anti-inflammatory drugs and basic β-blockers in a single step was carried out for the first time. It was shown that by designing an appropriate compartmentalized membrane envelope, the two classes of drugs could be electrokinetically extracted by a 300V direct current electrical potential. This method required only a very short 10-min extraction time from a pH-neutral sample, with a small amount (50μL) of organic solvent (1-octanol) as the acceptor phase. Analysis was carried out using gas chromatography-mass spectrometry after derivatization of the analytes. Extraction parameters such as extraction time, applied voltage, pH range, and concentration of salt added were optimized. The proposed EME technique provided good linearity with correlation coefficients from 0.982 to 0.997 over a concentration range of 1-200μgL-1. Detection limits of the drugs ranged between 0.0081 and 0.26μgL-1, while reproducibility ranged from 6 to 13% (n=6). Finally, the application of the new method to wastewater samples was demonstrated. © 2010 Elsevier B.V.
Source Title: Journal of Chromatography A
URI: http://scholarbank.nus.edu.sg/handle/10635/94811
ISSN: 00219673
DOI: 10.1016/j.chroma.2010.04.066
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