Please use this identifier to cite or link to this item:
|Title:||Rapid assembly and in situ screening of bidentate inhibitors of protein tyrosine phosphatases|
|Source:||Srinivasan, R., Uttamchandani, M., Yao, S.Q. (2006-02-16). Rapid assembly and in situ screening of bidentate inhibitors of protein tyrosine phosphatases. Organic Letters 8 (4) : 713-716. ScholarBank@NUS Repository. https://doi.org/10.1021/ol052895w|
|Abstract:||We have successfully designed and synthesized a small library of protein tyrosine phosphatase (PTP) inhibitors, in which the so-called "click chemistry" or Cu(I)-catalyzed 1,3-dipolar alkyne-azide coupling reaction was carried out for rapid assembly of 66 different bidentate compounds. Subsequent in situ enzymatic screening revealed a potential PTP1B inhibitor (IC50 = 4.7 μM) which is 10-100 fold more potent than other PTPs. © 2006 American Chemical Society.|
|Source Title:||Organic Letters|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Feb 14, 2018
WEB OF SCIENCETM
checked on Jan 22, 2018
checked on Feb 19, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.