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https://doi.org/10.1021/ol052895w
Title: | Rapid assembly and in situ screening of bidentate inhibitors of protein tyrosine phosphatases | Authors: | Srinivasan, R. Uttamchandani, M. Yao, S.Q. |
Issue Date: | 16-Feb-2006 | Citation: | Srinivasan, R., Uttamchandani, M., Yao, S.Q. (2006-02-16). Rapid assembly and in situ screening of bidentate inhibitors of protein tyrosine phosphatases. Organic Letters 8 (4) : 713-716. ScholarBank@NUS Repository. https://doi.org/10.1021/ol052895w | Abstract: | We have successfully designed and synthesized a small library of protein tyrosine phosphatase (PTP) inhibitors, in which the so-called "click chemistry" or Cu(I)-catalyzed 1,3-dipolar alkyne-azide coupling reaction was carried out for rapid assembly of 66 different bidentate compounds. Subsequent in situ enzymatic screening revealed a potential PTP1B inhibitor (IC50 = 4.7 μM) which is 10-100 fold more potent than other PTPs. © 2006 American Chemical Society. | Source Title: | Organic Letters | URI: | http://scholarbank.nus.edu.sg/handle/10635/94651 | ISSN: | 15237060 | DOI: | 10.1021/ol052895w |
Appears in Collections: | Staff Publications |
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