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|Title:||Rapid assembly and in situ screening of bidentate inhibitors of protein tyrosine phosphatases||Authors:||Srinivasan, R.
|Issue Date:||16-Feb-2006||Citation:||Srinivasan, R., Uttamchandani, M., Yao, S.Q. (2006-02-16). Rapid assembly and in situ screening of bidentate inhibitors of protein tyrosine phosphatases. Organic Letters 8 (4) : 713-716. ScholarBank@NUS Repository. https://doi.org/10.1021/ol052895w||Abstract:||We have successfully designed and synthesized a small library of protein tyrosine phosphatase (PTP) inhibitors, in which the so-called "click chemistry" or Cu(I)-catalyzed 1,3-dipolar alkyne-azide coupling reaction was carried out for rapid assembly of 66 different bidentate compounds. Subsequent in situ enzymatic screening revealed a potential PTP1B inhibitor (IC50 = 4.7 μM) which is 10-100 fold more potent than other PTPs. © 2006 American Chemical Society.||Source Title:||Organic Letters||URI:||http://scholarbank.nus.edu.sg/handle/10635/94651||ISSN:||15237060||DOI:||10.1021/ol052895w|
|Appears in Collections:||Staff Publications|
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